4-(Difluoromethyl)-3-(trifluoromethyl)phenol CAS 1261606-01-2
| CAS No. | 1261606-01-2 |
| Molecular Formula | C8H5F5O |
| Molecular Weight | 212.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Difluoromethyl)-3-(trifluoromethyl)phenol (C8H5F5O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
4-(Difluoromethyl)-3-(trifluoromethyl)phenol (CAS 1261606-01-2), molecular formula C8H5F5O and molecular weight 212.12 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-(Difluoromethyl)-3-(trifluoromethyl)phenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H5F5O |
| Molecular Weight | 212.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethyl Standards
- 1-(Difluoromethyl)-3-(trifluoromethoxy)benzene (CAS 1214326-70-1)
- 3-(Difluoromethyl)-5-(trifluoromethyl)phenol (CAS 1261482-74-9)
- 2-(Difluoromethyl)-4-(trifluoromethyl)phenol (CAS 1261500-20-2)
- 5-(Difluoromethyl)-2-(trifluoromethyl)phenol (CAS 1261778-70-4)
- 3-(Difluoromethyl)-5-(trifluoromethyl)pyridin-4-amine (CAS 1804655-11-5)
- 5-(Difluoromethyl)-2-(trifluoromethyl)pyridin-4-amine (CAS 1805173-71-0)
- 3-(Difluoromethyl)-4-(trifluoromethyl)pyridin-2-amine (CAS 1805302-56-0)
- 6-(Difluoromethyl)-3-(trifluoromethyl)pyridin-2-amine (CAS 1805302-67-3)
Recommended Standards
- 1-(Difluoromethoxy)-2-(difluoromethyl)-4-fluorobenzene (CAS 1261793-45-6)
- (5-Hexylthiophen-2-yl)boronic acid (CAS 1219791-07-7)
- 1-(3,5-Difluoropyridin-2-yl)-2,2,2-trifluoroethanamine (CAS 1270394-79-0)
- 1-(Difluoromethoxy)-2-(trifluoromethyl)benzene (CAS 1214388-57-4)
- [6-(methoxymethoxy)-1,3-dioxaindan-5-yl]methanol (CAS 1479045-54-9)
- 2-(Thiophen-2-yl)-1,2,3,4-tetrahydroquinazolin-4-one (CAS 13324-83-9)
- 4-{5-[2-(3,4-Difluoro-phenoxy)-ethyl]-4-methyl-thiazol-2-yl}-azepan-4-ol hydrochloride (CAS 1361111-81-0)
- 2-Bromopyrazolo[1,5-a]pyrimidin-7(1H)-one (CAS 2386629-55-4)
- n-[(dimethyl-1,2-oxazol-4-yl)methyl]-n-methylcyclopentanamine (CAS 1258693-65-0)
- 3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one (CAS 1434141-65-7)
- 1-(4-(Isobutylthio)phenyl)ethanol (CAS 1343337-38-1)
- 2-(3-Fluorobenzoyl)propanedinitrile (CAS 1463506-79-7)
- Ethyl 2-(4-ethoxy-3,5-difluorophenyl)-2-oxoacetate (CAS 1443304-69-5)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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