1-(Difluoromethoxy)naphthalene-2-carboxylic acid CAS 1261729-87-6
| CAS No. | 1261729-87-6 |
| Molecular Formula | C12H8F2O3 |
| Molecular Weight | 238.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
1-(Difluoromethoxy)naphthalene-2-carboxylic acid (CAS 1261729-87-6) is a high-purity analytical reference standard with the molecular formula C12H8F2O3 and a molecular weight of 238.19 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 1-(Difluoromethoxy)naphthalene-2-carboxylic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 238.19 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H8F2O3 |
| Molecular Weight | 238.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 5-[4-(difluoromethoxy)phenyl]-1,2,4-triazin-3-amine (CAS 1094271-28-9)
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- 4-(Difluoromethoxy)-1-naphthoic acid (CAS 1261884-90-5)
- 6-(Difluoromethoxy)-2-naphthoic acid (CAS 1261884-97-2)
- 3-(difluoromethoxy)naphthalene-2-carboxylic acid (CAS 929341-31-1)
- Methyl 3-(difluoromethoxy)-5-methoxythiophene-2-carboxylate (CAS 1710202-41-7)
- Ethyl 5-(difluoromethoxy)-4-fluoro-1-methyl-1H-pyrazole-3-carboxylate (CAS 1774902-68-9)
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Recommended Standards
- 4-(4-Bromobutyl)thiomorpholine (CAS 1247517-95-8)
- 3-(2,5-Difluorophenyl)-1-methyl-1h-pyrazole-5-carboxylic acid (CAS 1245171-63-4)
- Methyl 3-(trifluoromethylthio)pyrazine-2-carboxylate (CAS 1206524-66-4)
- 1-(2,4-Difluorobenzyl)-1H-pyrazole-4-carboxylic acid (CAS 1271611-01-8)
- (E)-4,4,5,5-tetramethyl-2-(2-(2-methyl-[1,1'-biphenyl]-3-yl)vinyl)-1,3,2-dioxaborolane (CAS 2171558-33-9)
- 5-(2-(Difluoromethoxy)phenyl)-4-ethyl-4h-1,2,4-triazole-3-thiol (CAS 832127-32-9)
- (2S)-2-(((4AR,6S,7R,8R,8aS)-7-acetamido-6-(benzyloxy)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)propanoic acid (CAS 730911-70-3)
- 4-Methoxy-N-(pyridin-2-ylmethyl)-1,3-benzothiazol-2-amine (CAS 1105195-04-7)
- Methyl 3-methyl-4,5-dihydroisoxazole-4-carboxylate (CAS 89464-50-6)
- 1-Bromo-4-(1-ethoxypropyl)naphthalene (CAS 1394023-91-6)
- (S)-tert-Butyl 3-(3H-imidazo[4,5-b]pyridin-3-yl)pyrrolidine-1-carboxylate (CAS 273757-03-2)
- [3-(1-Naphthyl)propyl]amine (CAS 24781-50-8)
- 1,3-Dioxepan-2-one (CAS 4427-94-5)
- Tau Peptide (304-318) trifluoroacetate salt (CAS 330456-49-0)
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