2-(Difluoromethoxy)-3-fluoro-3'-(trifluoromethoxy)biphenyl CAS 1261881-52-0
| CAS No. | 1261881-52-0 |
| Molecular Formula | C14H8F6O2 |
| Molecular Weight | 322.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(Difluoromethoxy)-3-fluoro-3'-(trifluoromethoxy)biphenyl is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(Difluoromethoxy)-3-fluoro-3'-(trifluoromethoxy)biphenyl (CAS 1261881-52-0), molecular formula C14H8F6O2 and molecular weight 322.20 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-(Difluoromethoxy)-3-fluoro-3'-(trifluoromethoxy)biphenyl (C14H8F6O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 322.20 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-(Difluoromethoxy)-3-fluoro-3'-(trifluoromethoxy)biphenyl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H8F6O2 |
| Molecular Weight | 322.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 4-(Difluoromethoxy)-3-fluoro-3'-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261611-39-5)
- 2-(Difluoromethoxy)-4-fluoro-2'-(trifluoromethoxy)biphenyl (CAS 1261649-98-2)
- 2-(Difluoromethoxy)-5-fluoro-4'-(trifluoromethoxy)biphenyl (CAS 1261797-16-3)
- 4'-(Difluoromethoxy)-3'-fluoro-2-(trifluoromethoxy)-1,1'-biphenyl (CAS 1261797-39-0)
- N-((2-(difluoromethoxy)phenyl)carbamothioyl)benzamide (CAS 674366-19-9)
- 5-(Difluoromethoxy)-3-iodo-1-methyl-1H-indazole (CAS 1422772-62-0)
- 6-(Difluoromethoxy)-3-iodo-1-methyl-1H-indazole (CAS 1822680-11-4)
- 3-(4-(Difluoromethoxy)phenyl)-2-mercaptoquinazolin-4(3h)-one (CAS 380340-06-7)
Recommended Standards
- 3-Bromo-6-phenyl-9H-carbazole (CAS 1303472-72-1)
- (5-Bromo-2-{methyl[2-(pyridin-2-yl)ethyl]amino}pyridin-3-yl)methanol (CAS 1306607-07-7)
- 1-(tert-Butyl) 2-ethyl (2R,4S)-4-bromo-1,2-pyrrolidinedicarboxylate (CAS 132622-76-5)
- 1-(tert-Butyl) 2-ethyl (2S,4S)-4-bromo-1,2-pyrrolidinedicarboxylate (CAS 132623-01-9)
- tert-Butyl 3-ethyl-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate (CAS 1356086-98-0)
- 6-(Tert-butylamino)picolinimidamide hydrochloride (CAS 1432681-69-0)
- 7,7-Dimethylbicyclo[2.2.1]heptan-1-yl sulfochloridate (CAS 62060-23-5)
- 1-(5-Bromo-2-methoxyphenyl)ethanol (CAS 16602-17-8)
- Borane 4-Methylmorpholine Complex (CAS 15648-16-5)
- Dimethyl 5-bromo-3-fluorophthalate (CAS 2222114-73-8)
- N1-Methyl-N3-(3-pyridinylmethyl)-b-alaninamide oxalate (CAS 1385694-19-8)
- [(2R)-1,4-Dioxan-2-yl]methanamine (CAS 1449010-18-7)
- (S,S)-Duthaler-Hafner reagent (CAS 140462-73-3)
- FMRF-Like Peptide from snail Helix aspersa (CAS 98495-35-3)
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