2-(Difluoromethoxy)-3'-(trifluoromethoxy)-3-(trifluoromethyl)biphenyl CAS 1261881-75-7
| CAS No. | 1261881-75-7 |
| Molecular Formula | C15H8F8O2 |
| Molecular Weight | 372.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Difluoromethoxy)-3'-(trifluoromethoxy)-3-(trifluoromethyl)biphenyl (CAS 1261881-75-7) is a high-purity analytical reference standard with the molecular formula C15H8F8O2 and a molecular weight of 372.21 g/mol.
Based on its molecular formula C15H8F8O2, 2-(Difluoromethoxy)-3'-(trifluoromethoxy)-3-(trifluoromethyl)biphenyl contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 372.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2-(Difluoromethoxy)-3'-(trifluoromethoxy)-3-(trifluoromethyl)biphenyl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H8F8O2 |
| Molecular Weight | 372.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 4-(Difluoromethoxy)-4'-(trifluoromethoxy)-3-(trifluoromethyl)-1,1'-biphenyl (CAS 1261448-29-6)
- 2-(Difluoromethoxy)-2'-(trifluoromethoxy)-3-(trifluoromethyl)biphenyl (CAS 1261558-89-7)
- 4-(Difluoromethoxy)-3'-(trifluoromethoxy)-2-(trifluoromethyl)-1,1'-biphenyl (CAS 1261660-09-6)
- 2-(Difluoromethoxy)-2'-(trifluoromethoxy)-5-(trifluoromethyl)biphenyl (CAS 1261728-92-0)
- 4-(Difluoromethoxy)-2'-(trifluoromethoxy)-2-(trifluoromethyl)-1,1'-biphenyl (CAS 1261729-19-4)
- 1-(4-(Difluoromethoxy)phenyl)-2-(isopropylthio)-5-(p-tolyl)-1H-imidazole (CAS 1226435-97-7)
- N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide (CAS 502887-71-0)
- 2-((4-(Difluoromethoxy)phenyl)amino)-N-(furan-2-ylmethyl)thiazole-4-carboxamide (CAS 1105229-84-2)
Recommended Standards
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(4-(trifluoromethyl)phenyl)thiophen-2-yl)boronate (CAS 1402234-05-2)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(3-(trifluoromethyl)phenyl)thiophen-2-yl)boronate (CAS 1402234-06-3)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (4-(4-(trifluoromethyl)phenyl)thiophen-2-yl)boronate (CAS 1402234-07-4)
- 3-Iodo-1-[(1-methyl-4-piperidinyl)methyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 1411763-96-6)
- spiro[1,3-benzodioxole-2,1'-cyclohexan]-6-amine (CAS 64179-41-5)
- 3,5-Diphenylpyridazine (CAS 1026-46-6)
- 6,7-dihydro-5H-quinazolin-8-one (CAS 89967-17-9)
- 3-(Furan-3-yl)-3-oxopropanenitrile (CAS 96220-13-2)
- N-(4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide (CAS 245747-08-4)
- 8-chloroimidazo[1,2-a]pyridine-3-carboxylic acid (CAS 1019023-77-8)
- Permethrin Impurity 4 (CAS 59897-92-6)
- Ethyl 4-(dimethylamino)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate (CAS 339030-85-2)
- 6-Formyl-1H-indole-2-carboxylic acid (CAS 136818-68-3)
- Exenatide (CAS 141758-74-9（free base）)
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