5-(3,5-Dichlorophenyl)-2-hydroxyisonicotinic acid CAS 1261905-95-6
| CAS No. | 1261905-95-6 |
| Molecular Formula | C12H7Cl2NO3 |
| Molecular Weight | 284.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(3,5-Dichlorophenyl)-2-hydroxyisonicotinic acid (CAS 1261905-95-6), molecular formula C12H7Cl2NO3 and molecular weight 284.09 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(3,5-Dichlorophenyl)-2-hydroxyisonicotinic acid (C12H7Cl2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H7Cl2NO3 |
| Molecular Weight | 284.09 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dichlorophenyl Standards
- 5-(2,5-Dichlorophenyl)-2-hydroxyisonicotinic acid (CAS 1261987-19-2)
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Recommended Standards
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- Methyl (2E)-3-(4-bromo-2-fluorophenyl)-2-cyanoprop-2-enoate (CAS 891066-76-5)
- 2,2'-(3-Chlorothiophene-2,5-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 942070-14-6)
- (2,3-Dihydro-5H-thiazolo[3,2-a]pyrimidin-6-yl)methanol (CAS 859850-74-1)
- 2-(2-(Furan-2-yl)-4-oxo-3,4-dihydrobenzo[b][1,4]thiazepin-5(2H)-yl)-N-(furan-2-ylmethyl)acetamide (CAS 863005-25-8)
- 5,6-Dinitro-4,7-bis((triisopropylsilyl)ethynyl)benzo[c][1,2,5]thiadiazole (CAS 1681015-89-3)
- 1-(2,6-Difluorophenoxy)propan-2-amine (CAS 883540-02-1)
- Promethazine EP Impurity C HCl (CAS 60113-77-1)
- 2-Amino-7-methyl-5-oxo-4-(2-(trifluoromethyl)phenyl)-4H,5H-pyrano[4,3-b]pyran-3-carbonitrile (CAS 315246-01-6)
- 5-Chloro-2-(bromomethyl)benzaldehyde (CAS 886041-44-7)
- 1-(tert-Butyl)-3-methyl-1H-pyrazole-5-carboxylic acid (CAS 175277-09-5)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
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