2',4'-Dichloro-3-fluoro-[1,1'-biphenyl]-4-carboxylic acid CAS 1261981-25-2
| CAS No. | 1261981-25-2 |
| Molecular Formula | C13H7Cl2FO2 |
| Molecular Weight | 285.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2',4'-Dichloro-3-fluoro-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261981-25-2), molecular formula C13H7Cl2FO2 and molecular weight 285.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2',4'-Dichloro-3-fluoro-[1,1'-biphenyl]-4-carboxylic acid (C13H7Cl2FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures 2',4'-Dichloro-3-fluoro-[1,1'-biphenyl]-4-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H7Cl2FO2 |
| Molecular Weight | 285.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Dichloro Standards
- 2',5'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1178448-60-6)
- 2',3'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1178742-29-4)
- 2',3'-Dichloro-4-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1178807-51-6)
- 2',5'-Dichloro-4-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1181596-14-4)
- 2',5'-Dichloro-3-fluoro-[1,1'-biphenyl]-4-carboxylic acid (CAS 1182971-83-0)
- 2',3'-Dichloro-3-fluoro-biphenyl-4-carboxylic acid (CAS 1183826-89-2)
- 2',3'-Dichloro-4-fluoro-biphenyl-2-carboxylic acid (CAS 1184060-56-7)
- 2',5'-Dichloro-4-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1184070-61-8)
Recommended Standards
- 4-(3,5-Dichlorophenyl)-3-fluorobenzoic acid (CAS 1261970-66-4)
- 2',4'-Dichloro-5-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261984-18-2)
- 3',5'-Dichloro-4-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261965-85-8)
- 5-Bromo-N-methoxy-N-methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxamide (CAS 1314734-57-0)
- 4-(3,4-Difluorophenyl)-4-oxobutyric acid (CAS 84313-94-0)
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