5-(2,6-Difluorophenyl)nicotinic acid CAS 1261998-47-3
| CAS No. | 1261998-47-3 |
| Molecular Formula | C12H7F2NO2 |
| Molecular Weight | 235.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-(2,6-Difluorophenyl)nicotinic acid (C12H7F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 5-(2,6-Difluorophenyl)nicotinic acid (CAS 1261998-47-3), a certified reference material (molecular formula C12H7F2NO2, MW 235.19 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 5-(2,6-Difluorophenyl)nicotinic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H7F2NO2 |
| Molecular Weight | 235.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 6-(3,5-Difluorophenyl)-nicotinic acid (CAS 1033844-89-1)
- 5-(3,5-Difluorophenyl)nicotinic acid (CAS 1048267-36-2)
- 5-(3,4-Difluorophenyl)nicotinic acid (CAS 1048486-16-3)
- 5-(3,4-Difluorophenyl)-picolinic acid (CAS 1225477-53-1)
- 2-(3,5-Difluorophenyl)nicotinic acid (CAS 1225477-61-1)
- 2-(3,5-Difluorophenyl)isonicotinic acid (CAS 1225477-70-2)
- 2-(3,4-Difluorophenyl)isonicotinic acid (CAS 1225511-01-2)
- 2-(3,4-Difluorophenyl)nicotinic acid (CAS 1225511-07-8)
Recommended Standards
- 5-(2,5-Difluorophenyl)picolinic acid (CAS 1261947-80-1)
- 1-(4-Nitrobenzoyl)cyclopropanecarboxylic acid 1287218-70-5 (CAS 1287218-70-5)
- 2-(2,6-Difluorophenyl)isonicotinic acid (CAS 1261930-34-0)
- (S)-3-(1,3-dioxoisoindolin-2-yl)-2-hydroxypropanoic acid (CAS 133319-36-5)
- 2-(Trifluoromethoxy)pyridin-4-amine (CAS 1221172-01-5)
- 3,3-Dimethyl-1-(4-pheny-2-thiazolyl)-1-phenyl-5-hydroxy[4,5]-bipyrazol (CAS 155299-83-5)
- Tert-butyl (6S,9aS)-6-methyloctahydro-2H-pyrazino[1,2-a]pyrazine-2-carboxylate (CAS 2506407-40-3)
- (1-(4-Propoxyphenyl)ethyl)hydrazine (CAS 1016764-43-4)
- (2,4-Bis(decyloxy)phenyl)methanol (CAS 2725764-22-5)
- 3-Methoxy-N-(naphtho[1,2-d]thiazol-2-yl)benzamide (CAS 325988-66-7)
- 2-(4,6-Dibromo-1H-indol-3-yl)acetonitrile (CAS 1227581-97-6)
- 4-(Piperazin-1-yl)cyclohexanecarboxylic acid ethyl ester (CAS 1416126-62-9)
- 1-[(2,5-Difluorophenyl)methyl]-4-methyl-1H-pyrazol-5-amine (CAS 1152964-00-5)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
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