(E)-3-(4-methoxy-3-(trifluoromethoxy)phenyl)acrylic acid CAS 1262018-46-1
| CAS No. | 1262018-46-1 |
| Molecular Formula | C11H9F3O4 |
| Molecular Weight | 262.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (E)-3-(4-methoxy-3-(trifluoromethoxy)phenyl)acrylic acid (C11H9F3O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies (E)-3-(4-methoxy-3-(trifluoromethoxy)phenyl)acrylic acid (CAS 1262018-46-1), a certified reference material (molecular formula C11H9F3O4, MW 262.18 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures (E)-3-(4-methoxy-3-(trifluoromethoxy)phenyl)acrylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H9F3O4 |
| Molecular Weight | 262.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related E Standards
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- 2-Methoxy-5-(pentafluoro-λ6-sulfanyl)benzaldehyde (CAS 1240256-83-0)
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- 2-(2-Methoxy-4,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1134082-52-2)
- 2-(4-Methoxy-2,6-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1208459-72-6)
- 2-(3-Methoxy-4,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1218790-19-2)
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Recommended Standards
- 2-((2,6-Dichlorobenzyl)(isopropyl)amino)ethanol (CAS 1249852-86-5)
- 2-((2,4-Dichlorobenzyl)(isopropyl)amino)ethanol (CAS 1249435-03-7)
- 4-(Oxetan-3-yloxy)-3-(trifluoromethyl)benzoic acid (CAS 1349716-44-4)
- 2-[(2,6-Dichloro-benzyl)-ethyl-amino]-ethanol (CAS 1249362-70-6)
- Methyl 5-bromo-2-methoxy-4-(trifluoromethyl)benzoate (CAS 1131587-97-7)
- tert-Butyl (2R,4S)-2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate (CAS 1018818-05-7)
- 5-{[(4-chlorophenyl)sulfanyl]methyl}-2-[3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophen-2-yl]pyrazolo[1,5-a]pyrimidin-7-ol (CAS 691868-62-9)
- Atropine Impurity 42 (CAS 13269-35-7)
- Tolvaptan Impurity 103 (CAS CATO-C4X-1955103)
- 3-Amino-2-phenylquinoline-4-carboxylic acid (CAS 36735-26-9)
- 1-(4,6-Diamino-1,3,5-triazin-2-yl)piperidin-4-ol (CAS 885268-31-5)
- (1-Phenethylpiperidin-3-yl)methanol (CAS 92322-05-9)
- 1-(Pyrrolidin-2-ylmethyl)-1H-imidazole (CAS 1177355-18-8)
- Osteogenic Growth Peptide (CAS 132996-61-3)
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