3-(Chlorosulfonyl)-4-fluoro-5-(trifluoromethyl)benzoic acid CAS 1263094-19-4
| CAS No. | 1263094-19-4 |
| Molecular Formula | C8H3ClF4O4S |
| Molecular Weight | 306.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(Chlorosulfonyl)-4-fluoro-5-(trifluoromethyl)benzoic acid (C8H3ClF4O4S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
3-(Chlorosulfonyl)-4-fluoro-5-(trifluoromethyl)benzoic acid (CAS 1263094-19-4) is a high-purity analytical reference standard with the molecular formula C8H3ClF4O4S and a molecular weight of 306.62 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF4O4S |
| Molecular Weight | 306.62 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Chlorosulfonyl Standards
- (4-(Chlorosulfonyl)phenyl)methylenediacetate (CAS 69232-47-9)
- Methyl 4-(4-(chlorosulfonyl)butoxy)benzoate (CAS 1375067-51-8)
- 2-(4-(Chlorosulfonyl)-2,5-dimethylphenoxy)ethyl acetate (CAS 91767-77-0)
- Ethyl 2-(4-(chlorosulfonyl)-2-ethylphenoxy)acetate (CAS 444613-16-5)
- Methyl 2-((4-(chlorosulfonyl)butyl)amino)benzoate (CAS 1338494-85-1)
- Ethyl 3-(chlorosulfonyl)thieno[3,2-c]pyridine-2-carboxylate (CAS 1955506-12-3)
- [6-(chlorosulfonyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]acetic acid (CAS 1000931-08-7)
- ethyl 5-(chlorosulfonyl)-2-methyl-3-nitrobenzoate (CAS 1154155-35-7)
Recommended Standards
- 5-[2-Chloro-3-(trifluoromethyl)phenoxy]-2-furoic acid (CAS 1160264-57-2)
- Hexaethylcyclotrisiloxane (CAS 2031-79-0)
- 6-Chloro-1,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (CAS 2667056-06-4)
- 1,3,5-Triethoxy-1,3,5-trimethyl-1,3,5-trisilinane (CAS 1747-56-4)
- 4-(((3-Methyloxetan-3-yl)methyl)amino)butanamide (CAS 1342474-35-4)
- Ethylcis-2-phenylcyclopropanecarboxylate (CAS 946-38-3)
- 4-Chloro-3-(n-(p-tolyl)sulfamoyl)benzoic acid (CAS 109029-98-3)
- 4-Bromo-5-(((tert-butyldimethylsilyl)oxy)methyl)thiazole (CAS 870063-22-2)
- 3-bromo-2-isocyanatobenzonitrile (CAS 1261508-23-9)
- Licofelone Acyl-β-D-glucuronide (CAS 1033702-58-7)
- 6-Methyl-2-((2-(piperidin-1-yl)ethyl)thio)-4-(trifluoromethyl)nicotinonitrile (CAS 317844-64-7)
- 3-(1-Ethyl-1h-pyrazol-5-yl)propan-1-ol (CAS 1343700-81-1)
- MA 2029 (CAS 287206-61-5)
- Tirzepatide-d7 Ditrifluoroacetate (CAS CATO-CPTD788698)
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