1-(4-Bromo-3-chloro-2-methylphenyl)thiourea CAS 1263376-09-5

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(4-Bromo-3-chloro-2-methylphenyl)thiourea.

1-(4-Bromo-3-chloro-2-methylphenyl)thiourea (CAS 1263376-09-5) is a high-purity analytical reference standard with the molecular formula C8H8BrClN2S and a molecular weight of 279.58 g/mol.

The molecular framework of 1-(4-Bromo-3-chloro-2-methylphenyl)thiourea (C8H8BrClN2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-(4-Bromo-3-chloro-2-methylphenyl)thiourea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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