Valsartan Impurity 6 HCl CAS 1266616-11-8
| CAS No. | 1266616-11-8 |
| Molecular Formula | C18H21N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C18H21N5HCl, Valsartan Impurity 6 HCl contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 343.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Valsartan Impurity 6 HCl (CAS 1266616-11-8, C18H21N5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H21N5 HCl |
| Molecular Weight | 343.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Valsartan Standards
- Valsartan Impurity 121 (CAS 1000986-63-9)
- (S)-(-)-Valsartan-d8 (valine-d8) (CAS 1089736-72-0)
- Valsartan-d9 (Major) (CAS 1089736-73-1)
- Valsartan Impurity 13 ( Valproic Acid EP Impurity A ) (CAS 109-52-4)
- Valsartan Impurity 35 HCl (CAS 1111177-20-8)
- Valsartan Impurity 9 (CAS 1111177-30-0)
- Valsartan Impurity 10 (CAS 114772-54-2)
- Valsartan Impurity 82 (CAS 1189547-11-2)
Recommended Standards
- Salbutamol Impurity 112 (CAS CATO-C4X-1176112)
- Metaraminol impound 105 (CAS CATO-C4X-2252105)
- Glycopyrronium Bromide impurity 16 (CAS 16098-80-9)
- 1,2-Bis(2,5-dimethylfuran-3-yl)disulfane (CAS 28588-73-0)
- 3-Bromo-6-(trifluoromethyl)pyridine-2-carboxylic Acid Methyl Ester (CAS 1211538-62-3)
- Ethyl 2-chloro-5-iodothiazole-4-carboxylate (CAS 1823953-41-8)
- 5-(4,4-Difluoropiperidin-1-yl)-2-(trifluoromethyl)pyridine (CAS 1707358-20-0)
- 1-(5-Fluoropyridin-2-yl)ethanamine (CAS 915720-57-9)
- 5-[(3-Chlorophenyl)sulfanyl]-N-(4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxamide (CAS 303998-08-5)
- Semaglutide impurity 210 (CAS CATO-C4X-2226210)
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