8-Fluoro-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid CAS 1268148-25-9
| CAS No. | 1268148-25-9 |
| Molecular Formula | C11H8FNO3 |
| Molecular Weight | 221.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 221.18 g/mol gives 8-Fluoro-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
8-Fluoro-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid (CAS 1268148-25-9) is a high-purity analytical reference standard with the molecular formula C11H8FNO3 and a molecular weight of 221.18 g/mol.
The molecular framework of 8-Fluoro-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid (C11H8FNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 8-Fluoro-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8FNO3 |
| Molecular Weight | 221.18 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
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- Methyl 8-fluoro-4-hydroxyquinoline-2-carboxylate (CAS 1078130-52-5)
- 2-(8-Fluoro-4-oxoquinolin-1(4H)-yl)acetic acid (CAS 1092288-70-4)
Recommended Standards
- 6-Fluoro-1-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid (CAS 1266896-86-9)
- Ethyl 1-methyl-4-(trifluoromethyl)-1H-pyrrole-3-carboxylate (CAS 130511-76-1)
- 7-Fluoro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 1266727-21-2)
- 2-(7-Fluoro-4-oxoquinolin-1(4H)-yl)acetic acid (CAS 1315345-14-2)
- 2-(2-(4-Hydroxypiperidin-1-yl)-1H-benzo[d]imidazol-1-yl)nicotinonitrile (CAS 1314356-29-0)
- 2-(3-ethoxyoxetan-3-yl)ethanamine (CAS 1894125-34-8)
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- 3-Amino-2-phenylpyridine (CAS 101601-80-3)
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- Semaglutide impurity 31 (CAS CATO-C4X-222631)
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