1-(4-Chloro-3-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid CAS 1270831-90-7
| CAS No. | 1270831-90-7 |
| Molecular Formula | C11H9ClFNO3 |
| Molecular Weight | 257.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(4-Chloro-3-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(4-Chloro-3-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 1270831-90-7), molecular formula C11H9ClFNO3 and molecular weight 257.65 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(4-Chloro-3-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (C11H9ClFNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-(4-Chloro-3-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H9ClFNO3 |
| Molecular Weight | 257.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-(3-Chloro-2-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 1152531-47-9)
- 3-Chloro-7-nitrobenzo[b]thiophene-2-carboxylic acid (CAS 1210527-55-1)
- 1-(2-Chloro-5-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 1291837-07-4)
- 1-(2-Chloro-4-fluorobenzoyl)azetidine-3-carboxylic acid (CAS 1407081-62-2)
- 1-(2-Chloro-6-fluorobenzoyl)azetidine-3-carboxylic acid (CAS 1410085-77-6)
- 2-Chloro-8-fluoro-6,7-dimethoxyquinazolin-4-amine (CAS 1515883-78-9)
- 1-(3-Chloro-4-fluorophenyl)-2-oxopyrrolidine-3-carboxylic acid (CAS 618070-34-1)
- 1-(3-Chloro-4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 696647-51-5)
Recommended Standards
- 4-(2-Chloro-5-(trifluoromethyl)phenyl)pyridine (CAS 4393-93-5)
- 3-Chloro-2-phenyl-5-(trifluoromethyl)pyridine (CAS 370878-67-4)
- 3-(2-Chloro-5-(trifluoromethyl)phenyl)pyridine (CAS 4393-94-6)
- 2-Amino-3-chloro-6-(difluoromethyl)pyridine-4-sulfonamide (CAS 1803669-33-1)
- 4-Fluoro-4'-methoxy-1,1'-biphenyl (CAS 450-39-5)
- Benzyl (1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate hydrochloride (CAS 1454648-83-9)
- 4-(2-Naphthylmethyl)piperidine Hydrochloride (CAS 252563-97-6)
- rel-Ethyl (1R,2R)-2-(3-bromophenyl)cyclopropane-1-carboxylate (CAS 114095-58-8)
- 3-(4-((2-Aminoethyl)amino)-1,2,5-oxadiazol-3-yl)-4-(3-bromo-4-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one (CAS 1204670-56-3)
- 5-Bromo-2-(piperidin-4-yl)pyrimidine (CAS 1256818-45-7)
- 2-Amino-2-(3,5-dichlorophenyl)acetic Acid Hydrochloride (CAS 1137014-87-9)
- 7-Amino-4-(methoxymethyl)-2H-chromen-2-one (CAS 175205-10-4)
- 2,2-Dimethylhex-5-enenitrile (CAS 84173-95-5)
- Casein Kinase II Receptor Peptide (CAS 198481-81-1)
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