4-Chloro-3-Fluoropyridine 1-Oxide CAS 127108-51-4
| CAS No. | 127108-51-4 |
| Molecular Formula | C5H3ClFNO |
| Molecular Weight | 147.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-3-Fluoropyridine 1-Oxide.
4-Chloro-3-Fluoropyridine 1-Oxide (CAS 127108-51-4) is a high-purity analytical reference standard with the molecular formula C5H3ClFNO and a molecular weight of 147.53 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 4-Chloro-3-Fluoropyridine 1-Oxide is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 147.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3ClFNO |
| Molecular Weight | 147.53 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-2-fluoropyridin-3-ol (CAS 1003711-65-6)
- 2-Chloro-3-fluoro-4-hydroxypyridine (CAS 1184172-46-0)
- 2-Chloro-5-fluoropyridin-4-ol (CAS 1196153-96-4)
- 6-Chloro-4-fluoropyridin-3-ol (CAS 1211530-63-0)
- 3-Chloro-5-fluoro-4-hydroxypyridine (CAS 1214327-70-4)
- 3-Chloro-5-fluoropyridin-2(1H)-one (CAS 1214345-43-3)
- 3-Chloro-5-fluoropyridine 1-oxide (CAS 1221793-68-5)
- 3-Chloro-2-fluoropyridin-4-ol (CAS 1227499-28-6)
Recommended Standards
- 4-Chloro-3-fluoropyridin-2-ol (CAS 1227596-29-3)
- 6-Chloro-3-fluoropyridin-2(1H)-one (CAS 1369769-03-8)
- 5-Chloro-6-fluoropyridin-2(1H)-one (CAS 1227596-11-3)
- 4-Chloro-5-fluoropyridin-3-ol (CAS 1393553-75-7)
- 2-(5-Cyano-6-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid (CAS 5900-45-8)
- 2-[(4-Bromophenyl)sulfanyl]-N-(prop-2-en-1-yl)acetamide (CAS 339097-60-8)
- 6-(Benzyloxy)benzo[c][1,2]oxaborol-1(3H)-ol (CAS 1222010-47-0)
- methyl 3-(2-fluorophenyl)-1H-pyrazole-5-carboxylate (CAS 1239717-20-4)
- 3-Chloro-N-(4-chlorobenzyl)benzamide (CAS 446855-38-5)
- (E)-2-methoxy-5-(prop-1-en-1-yl)phenol (CAS 19784-98-6)
- Benzofuran-3-acetic Acid (CAS 64175-51-5)
- tert-Butyl 3-(cyclopropylamino)azetidine-1-carboxylate (CAS 1342433-96-8)
- 4-Iodo-1H-pyrazol-3-amine (CAS 81542-51-0)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788677)
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