Sitafloxacin Isomer Impurity 3(SSR) CAS 127254-11-9
| CAS No. | 127254-11-9 |
| Molecular Formula | C19H18ClF2N3O3 |
| Molecular Weight | 409.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sitafloxacin Isomer Impurity 3(SSR) (C19H18ClF2N3O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Sitafloxacin Isomer Impurity 3(SSR) (CAS 127254-11-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H18ClF2N3O3 and a molecular weight of 409.81 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H18ClF2N3O3 |
| Molecular Weight | 409.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Sitafloxacin Standards
- Sitafloxacin Isomer Impurity 4(RSR) (CAS 127199-06-8)
- Sitafloxacin Isomer Impurity (RRR) (CAS CATO-C4X-11555)
- Sitafloxacin impurity 58 (CAS CATO-C4X-115558)
- Sitafloxacin Isomer Impurity 6(SRR) (CAS CATO-C4X-11556)
- Sitafloxacin Isomer Impurity 7(SSS) (CAS CATO-C4X-11557)
- Sitafloxacin Isomer Impurity 8(RSS) (CAS CATO-C4X-11558)
- Sitafloxacin Isomer Impurity 9(RRS) (CAS 127254-10-8)
- Sitafloxacin (CAS 127254-12-0)
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