2-Bromo-5-chloropyridin-3-ol CAS 127561-70-0
| CAS No. | 127561-70-0 |
| Molecular Formula | C5H3BrClNO |
| Molecular Weight | 208.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Bromo-5-chloropyridin-3-ol (CAS 127561-70-0) is a high-purity analytical reference standard with the molecular formula C5H3BrClNO and a molecular weight of 208.44 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, 2-Bromo-5-chloropyridin-3-ol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 208.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3BrClNO |
| Molecular Weight | 208.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 2-Bromo-6-chloropyridin-3-ol (CAS 1020253-16-0)
- 5-Bromo-4-chloro-2-pyrimidinamine (CAS 1044767-99-8)
- 2-Bromo-5-chloropyridin-4-ol (CAS 1196145-66-0)
- 5-Bromo-2-chloro-4-hydroxypyridine (CAS 1196146-82-3)
- 4-Bromo-5-chloropyridin-3-ol (CAS 1211517-85-9)
- 3-Bromo-2-chloropyridin-4-ol (CAS 1211519-66-2)
- 4-Bromo-6-chloropyridin-3-ol (CAS 1211520-41-0)
- 2-Bromo-3-chloropyridin-4-ol (CAS 1211525-75-5)
Recommended Standards
- 4-Bromo-2-chloropyrimidin-5-amine (CAS 1266119-47-4)
- 3-Bromo-2-chloro-5-hydroxypyridine (CAS 130115-85-4)
- 5-Bromo-4-chloropyridin-3-ol (CAS 1256813-87-2)
- 2-Bromo-3-chloro-5-hydroxypyridine (CAS 130284-56-9)
- 5-BRomo-2-(oxetan-3-yloxy)pyrimidine (CAS 1207174-86-4)
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- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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