2,6-Difluoro-N-[[[2-Methyl-4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]Amino]Carbonyl]Benzamide CAS 94157-91-2
| CAS No. | 94157-91-2 |
| Molecular Formula | C18H12F8N2O3 |
| Molecular Weight | 456.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,6-Difluoro-N-[[[2-Methyl-4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]Amino]Carbonyl]Benzamide.
2,6-Difluoro-N-[[[2-Methyl-4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]Amino]Carbonyl]Benzamide (CAS 94157-91-2), molecular formula C18H12F8N2O3 and molecular weight 456.29 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2,6-Difluoro-N-[[[2-Methyl-4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]Amino]Carbonyl]Benzamide (C18H12F8N2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 456.29 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H12F8N2O3 |
| Molecular Weight | 456.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoro Standards
- N-(2,4-difluoro-3-(hydroxy(5-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)phenyl)propane-2-sulfonamide (CAS 918523-56-5)
- 1-(5-(3,4-difluoro-2-(2-(1,3,5-Trimethyl-1H-pyrazol-4-yl)ethoxy)phenyl)-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine (CAS 2059148-82-0)
- 3,4-Difluoro-N-[(1S)-1-[6-[4-(2-pyridinyl)-1-piperazinyl]-2-pyrazinyl]ethyl]benzenepropanamide (CAS 2244989-34-0)
- 1-[(2,2-Difluoro-2H-1,3-benzodioxol-5-yl)methyl]-2-oxo-N-[4-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide (CAS 400082-70-4)
- 1-(Difluoro(phenylsulfonyl)methyl)-3,3-dimethyl-1,3-dihydro-1lambda3-benzo[d][1,2]iodaoxole (CAS 1052174-67-0)
- 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)benzamide (CAS 391209-55-5)
- Methyl 3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-5-nitrobenzoate (CAS 836602-27-8)
- ((5,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl)oxy)triisopropylsilane (CAS 2858674-32-3)
Recommended Standards
- 2-(methylsulfonyl)-4-(tributylstannyl)thiazole (CAS 1245816-14-1)
- N-[(1E)-{[(2-bromophenyl)methoxy]imino}methyl]-4-methoxy-2-phenoxypyridine-3-carboxamide (CAS 478262-48-5)
- 2-(Methylsulfonyl)-5-(tributylstannyl)thiazole (CAS 1245816-12-9)
- 2,4-Dichloro-5-(n-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)sulfamoyl)benzoic acid (CAS 380347-78-4)
- 1,8-Naphthyridine-2-butanoic acid (CAS 886362-95-4)
- [(4-isopropoxy-3-thienyl)methyl]amine (CAS 1428234-11-0)
- 4-Fluoro-1-methyl-2-vinylbenzene (CAS 1692309-89-9)
- Methyl 4-((thiazol-4-ylmethyl)amino)picolinate (CAS 1508578-62-8)
- 1428577-87-0 5-Chloro-1-(~2~H_3_)methyl-4-nitro-1H-pyrazole DTXSID40857353 (CAS 1428577-87-0)
- N-(5-(1-Ethylcyclohexyl)isoxazol-3-yl)-2,6-dimethoxybenzamide (CAS 82558-52-9)
- 1-(5-Amino-3-(trifluoromethyl)-2,3-dihydro-1H-1,2,4-triazol-1-yl)ethanone (CAS 2767502-00-9)
- [5-(propan-2-yl)-4H-1,2,4-triazol-3-yl]methanamine hydrochloride (CAS 1820707-63-8)
- N-Hexylhydroxylamine hydrochloride (CAS 167388-34-3)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com