2-(Trifluoromethoxy)benzimidamide hydrochloride CAS 127979-76-4
| CAS No. | 127979-76-4 |
| Molecular Formula | C8H7F3N2O |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Trifluoromethoxy)benzimidamide hydrochloride (CAS 127979-76-4) is a high-purity analytical reference standard with the molecular formula C8H7F3N2OHCl and a molecular weight of 240.61 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 2-(Trifluoromethoxy)benzimidamide hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 240.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F3N2O HCl |
| Molecular Weight | 240.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethoxy Standards
- 3-Methyl-5-(trifluoromethoxy)benzaldehyde (CAS 1000339-55-8)
- 1000339-57-0 3-Methyl-5-(trifluoromethoxy)phenylacetic acid MFCD08741405 (CAS 1000339-57-0)
- 3-(4-(Trifluoromethoxy)phenyl)propan-1-ol (CAS 1000519-40-3)
- 2-[4-(Trifluoromethoxy)phenyl]cyclopropan-1-amine (CAS 1001316-74-0)
- 4-(4-(Trifluoromethoxy)phenyl)piperidine hydrochloride (CAS 1004618-85-2)
- 3-Methyl-5-(trifluoromethoxy)cinnamic acid (CAS 1005378-68-6)
- 5-(Trifluoromethoxy)-2-(trifluoromethyl)-1H-indole (CAS 1007235-31-5)
- (4-(Trifluoromethoxy)benzyl)hydrazine 2,2,2-trifluoroacetate (CAS 1007599-47-4)
Recommended Standards
- tert-Butyl 3-hydroxy-6-fluoro-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate (CAS 1965310-09-1)
- JWH-122 4-Hydroxypentyl (CAS 1537889-07-8)
- 5-Amino-3-bromo-1-methylpyrazole (CAS 1357471-14-7)
- Hyoscyamine sulfate (CAS 620-61-1)
- TC-2216, >98% (HPLC) (CAS 646055-67-6)
- N-(tert-butyl)-6-methyl-3-(3-(trifluoromethyl)phenyl)-1,2,4-triazin-5-amine (CAS 339103-65-0)
- 4-PPBP maleate, 98% (CAS 207572-62-1)
- Peramivir Impurity 129 (CAS CATO-C4X-1833129)
- 3-(4-Chlorophenyl)-2,4-dimethylpropiophenone (CAS 898787-97-8)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
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