Telmisartan Impurity 55 CAS 128-08-5
| CAS No. | 128-08-5 |
| Molecular Formula | C4H4BrNO2 |
| Molecular Weight | 177.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Telmisartan Impurity 55 (CAS 128-08-5) is a certified pharmaceutical impurity reference standard with the molecular formula C4H4BrNO2 and a molecular weight of 177.98 g/mol.
The molecular framework of Telmisartan Impurity 55 (C4H4BrNO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C4H4BrNO2 |
| Molecular Weight | 177.98 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Telmisartan Standards
- Telmisartan Impurity 86 (CAS CATO-C4X-135986)
- Telmisartan Impurity 79 (CAS CATO-C4X-135979)
- Telmisartan Impurity 29 (CAS 1132638-92-6)
- Telmisartan Impurity 88 (CAS CATO-C4X-135988)
- Telmisartan Impurity 89 (CAS CATO-C4X-135989)
- Telmisartan Impurity 40 (CAS 2840-51-9)
- Telmisartan Impurity 52 (CAS 7356-11-8)
- Telmisartan Impurity 23 (CAS 84859-27-8)
Recommended Standards
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- 2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide (CAS 578746-81-3)
- Choline Fenofibrate Impurity 31 (CAS CATO-C4X-101831)
- 2-Chloro-N-cyclopentyl-5-fluoropyrimidin-4-amine (CAS 1338495-23-0)
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