Tryptophan EP Impurity F CAS 145545-23-9
| CAS No. | 145545-23-9 |
| Molecular Formula | C9H12N2O2 |
| Molecular Weight | 180.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tryptophan EP Impurity F (CAS 145545-23-9, C9H12N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Tryptophan EP Impurity F is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 180.20 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tryptophan EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H12N2O2 |
| Molecular Weight | 180.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
Related Tryptophan Standards
Recommended Standards
- 2,3-Dimethoxybenzimidamide (CAS 144650-01-1)
- (S)-Methyl 3-(1-hydroxyethyl)benzoate (CAS 1459711-61-5)
- Benzyl 3-Hydroxypropionate (CAS 14464-10-9)
- 4-(Aminomethyl)-N-methoxybenzamide (CAS 1465580-81-7)
- Ketotifen Impurity 29 (CAS CATO-C4X-204629)
- Canagliflozin Impurity 57 (CAS CATO-C4X-112357)
- Fenfluramine Impurity 8 (CAS 621-45-4)
- 5-Nitro-2-(pyridin-2-yl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 1774903-48-8)
- 2-(4-(5-Nitropyridin-2-yl)piperazin-1-yl)ethan-1-ol (CAS 747354-44-5)
- 2-(Chloromethyl)-3,6-diamino-4-(difluoromethyl)pyridine (CAS 1806783-47-0)
- Ethyl 4-fluoro-3-isopropoxybenzoate (CAS 1394960-25-8)
- N-methyl-2-((5-nitroimidazo[2,1-b]thiazol-6-yl)thio)acetamide (CAS 339022-45-6)
- Specnuezhenide (CAS 39011-92-2)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
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