2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one CAS 1281566-89-9
| CAS No. | 1281566-89-9 |
| Molecular Formula | C11H6ClF3N2O |
| Molecular Weight | 274.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1281566-89-9), molecular formula C11H6ClF3N2O and molecular weight 274.63 g/mol, is a CATO reference standard with documented purity and traceability.
2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (C11H6ClF3N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(3-chlorophenyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H6ClF3N2O |
| Molecular Weight | 274.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chlorophenyl Standards
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- 2-(4-Chlorophenyl)-5-nitrobenzo[d]oxazole (CAS 962-25-4)
- 2-(2-Chlorophenyl)-6-fluoro-4H-chromen-4-one (CAS 527751-46-8)
- 2-(4-Chlorophenyl)-6-fluoro-4H-chromen-4-one (CAS 288400-97-5)
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Recommended Standards
- 2-Chloro-4-(4-(trifluoromethyl)phenoxy)pyrimidine (CAS 1208087-07-3)
- 2-Chloro-N-(4-(trifluoromethyl)pyridin-2-yl)pyrimidin-4-amine (CAS 1361197-71-8)
- 1-Phenyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl chloride (CAS 1003579-29-0)
- 6-Chloro-3-(3-(trifluoromethyl)phenyl)pyridazin-4-ol (CAS 138651-04-4)
- α-(Dicyclohexylphosphino)-N-methyl-N-(phenylmethyl)benzenemethanamine (CAS 219711-45-2)
- 5,5-Dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-7-amine (CAS 1022971-79-4)
- 1-Bromo-2,3-bis(difluoromethyl)benzene (CAS 2641906-43-4)
- 6-methoxy-2,4-dimethylpyridine-3-carbaldehyde (CAS 819069-58-4)
- 4-(4-Fluorophenyl)-1,3-thiazole-2-thiol (CAS 42365-73-1)
- 1-Phenylcyclopentane-1-carboximidamide (CAS 55753-43-0)
- 1365962-57-7 6-tert-Butyl 3-ethyl 2-[(2-chloropropanoyl)amino]-4,7-dihydrothieno[2,3-c]pyridine-3,6(5H)-dicarboxylate MFCD22056598 (CAS 1365962-57-7)
- Pyr-Phe-Leu-pNA (CAS 85901-57-1)
- 2-(4-Chlorophenyl)-N,4-dimethyl-1,3-thiazole-5-carboxamide (CAS 320420-81-3)
- C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 127869-51-6)
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