2-(2-Chlorophenyl)-4-cyclopropylpyrimidine-5-carboxylic acid CAS 1283933-33-4
| CAS No. | 1283933-33-4 |
| Molecular Formula | C14H11ClN2O2 |
| Molecular Weight | 274.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 274.70 g/mol gives 2-(2-Chlorophenyl)-4-cyclopropylpyrimidine-5-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(2-Chlorophenyl)-4-cyclopropylpyrimidine-5-carboxylic acid (CAS 1283933-33-4), molecular formula C14H11ClN2O2 and molecular weight 274.70 g/mol, is a CATO reference standard with documented purity and traceability.
2-(2-Chlorophenyl)-4-cyclopropylpyrimidine-5-carboxylic acid (C14H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(2-Chlorophenyl)-4-cyclopropylpyrimidine-5-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H11ClN2O2 |
| Molecular Weight | 274.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- 2-(4-Chlorophenyl)-4-cyclopropylpyrimidine-5-carboxylic acid (CAS 1284418-58-1)
- (3-Chlorophenyl)(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methanone (CAS 727994-89-0)
- 1-(2-Chlorophenyl)-3,4-dimethylpyrano[2,3-c]pyrazol-6(1H)-one (CAS 85094-16-2)
- 1-(3-Chlorophenyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea (CAS 448189-13-7)
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- 1-(4-Chlorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione (CAS 65599-34-0)
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- 2-Acetyl-4-chlorophenyl benzoate (CAS 4010-29-1)
Recommended Standards
- 2-Chloro-4-(2,4-dimethoxyphenyl)nicotinonitrile (CAS 1267261-23-3)
- 2-Chloro-4-(3,4-dimethoxyphenyl)nicotinonitrile (CAS 1266991-33-6)
- 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-sulfonyl chloride (CAS 1305652-34-9)
- 3'-Acetyl-5-chloro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261942-86-2)
- N-(3-Acetylphenyl)-2,4-dimethoxybenzamide (CAS 545353-16-0)
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- 4-Chloroisoquinolin-8-amine (CAS 1824065-49-7)
- 2-[(2,2,2-trifluoroethyl)amino]-6-(trifluoromethyl)pyridine-3-carboxylic acid (CAS 1538422-47-7)
- (1-(5-Fluoro-2-methylphenyl)cyclopropyl)methanamine (CAS 1540833-62-2)
- Nicotinamide (2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl sulfate (CAS 1713228-05-7)
- 1-Bromo-4-fluoro-2-methyl-3-nitrobenzene (CAS 1227210-35-6)
- (3'-Fluoro[1,1'-biphenyl]-4-yl)acetonitrile (CAS 893734-08-2)
- 2-tert-butyl-4-(piperazin-1-ylmethyl)-1,3-thiazole (CAS 1094661-15-0)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
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