Telmisartan EP Impurity A CAS 1282554-35-1
| CAS No. | 1282554-35-1 |
| Molecular Formula | C19H20N4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Telmisartan EP Impurity A.
As a process- or degradation-related impurity, Telmisartan EP Impurity A (CAS 1282554-35-1, C19H20N4H2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Telmisartan EP Impurity A (C19H20N4H2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H20N4 H2O |
| Molecular Weight | 322.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 4 |
Related Telmisartan Standards
- Telmisartan Impurity 41 (CAS 1004548-55-3)
- Telmisartan Impurity 59 (CAS 1016696-74-4)
- Telmisartan EP Impurity B (CAS 1026353-20-7)
- Telmisartan Impurity 15 (CAS 1026438-56-1)
- Telmisartan Impurity N20 (CAS 1083158-65-9)
- Telmisartan Impurity 45 (CAS 1098100-86-7)
- Telmisartan Impurity 2 (CAS 1113-26-4)
- Telmisartan Aldehyde Impurity (CAS 112804-58-7)
Recommended Standards
- L-Ornithine L-Aspartate Impurity 7 (CAS 886996-37-8)
- Edaravone impurity 44 (CAS CATO-C4X-106244)
- Ketorolac Impurity 24 (CAS 141054-41-3)
- N-[9-[(2R,4R,5R)-4-fluoro-5-(hydroxymethyl)-3-oxo-tetrahydrofuran-2-yl]-6-oxo-3H-purin-2-yl]-2-methyl-propanamide (CAS 2740545-09-7)
- Ethyl 2-ethoxy-7-hydroxybenzo[d][1,3]dioxole-5-carboxylate (CAS 733746-42-4)
- Methyl (R)-3-(Dibenzylamino)-2-fluoropropanoate (CAS 88099-68-7)
- Pimavanserin Impurity 6 (CAS 359878-47-0)
- 5-Chloro-3-phenyl-2-(thiophen-2-yl)-1H-indole (CAS 338748-67-7)
- N-(3-Azidopropyl)biotinamide (CAS 908007-17-0)
- Neuroendocrine Regulatory Peptide-1 (rat) (CAS 954420-51-0)
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