4-Formyl-6-(trifluoromethyl)picolinic acid CAS 1289075-03-1
| CAS No. | 1289075-03-1 |
| Molecular Formula | C8H4F3NO3 |
| Molecular Weight | 219.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Formyl-6-(trifluoromethyl)picolinic acid (C8H4F3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
4-Formyl-6-(trifluoromethyl)picolinic acid (CAS 1289075-03-1), molecular formula C8H4F3NO3 and molecular weight 219.12 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4F3NO3 |
| Molecular Weight | 219.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Formyl Standards
- 2-Formyl-6-(trifluoromethyl)nicotinic acid (CAS 1289132-83-7)
- 3-Formyl-5-methoxy-1h-indole-2-carboxylic acid (CAS 57646-80-7)
- 3-Formyl-6-methoxy-1h-indole-2-carboxylic acid (CAS 858752-19-9)
- Methyl 6-formyl-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-2-carboxylate (CAS 1823530-02-4)
- 4-(5-Formyl-2-methoxyphenoxy)butanenitrile (CAS 1016842-76-4)
- 4-(2-Formyl-6-methoxyphenoxy)butanenitrile (CAS 928712-02-1)
- 3-Formyl-5-methylbenzenesulfonyl chloride (CAS 1393546-56-9)
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Recommended Standards
- 8-bromo-3-methyl-imidazo[1,2-a]pyridine (CAS 1288990-82-8)
- 7-bromo-3-methyl-imidazo[1,2-a]pyridine (CAS 1276026-68-6)
- 5-bromo-6-methylimidazo[1,2-a]pyridine (CAS 1346157-13-8)
- 5-bromo-8-methyl-imidazo[1,2-a]pyridine (CAS 1257294-47-5)
- 1,3-Isobenzofurandione, polymer with 1,2-ethanediol, 2,5-furandione and 2,2'-oxybis[ethanol] (CAS 28679-80-3)
- 4-(Phenylamino)pent-3-en-2-one (CAS 7294-89-5)
- (4AR,6R,7R,8R,8aS)-6-(4-nitrophenoxy)-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diol (CAS 250674-88-5)
- 4-Diphenyl-1-naphthaleneboronic acid (CAS 881811-83-2)
- methyl 2-amino-3-cycloheptyl-propanoate (CAS 764643-84-7)
- Methyl 2-[2-(morpholin-4-yl)-4-phenyl-1,3-thiazol-5-yl]acetate (CAS 685107-42-0)
- 2-{6-[(4-chlorophenyl)sulfanyl]pyridazin-3-yl}-2-(2,4-dichlorophenyl)acetonitrile (CAS 339026-64-1)
- 4-((2-Chlorothiazol-5-yl)methoxy)benzonitrile (CAS 339018-30-3)
- 2-(4-(1-Hexyl-1H-indol-2-yl)phenyl)acetic acid (CAS 88561-09-5)
- Liraglutide Impurity 31 (CAS CATO-C4X-199231)
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