Tacrolimus Impurity 32 CAS 129039-81-2
| CAS No. | 129039-81-2 |
| Molecular Formula | C43H65NO12 |
| Molecular Weight | 787.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tacrolimus Impurity 32 (C43H65NO12) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Tacrolimus Impurity 32 (CAS 129039-81-2, C43H65NO12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C43H65NO12 |
| Molecular Weight | 787.98 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus Impurity 3 (CAS CATO-C4X-13003)
- Tacrolimus EP Impurity I (CAS 104987-16-8)
- Tacrolimus Impurity 54 (CAS CATO-C4X-130054)
- Tacrolimus Impurity 58 (CAS CATO-C4X-130058)
- Tacrolimus 31 DMT (CAS 135635-47-1)
- Tacrolimus 15-DMT (CAS 151039-41-7)
- Tacrolimus 31-DMT (CAS 127984-76-3)
- Tacrolimus EP Impurity C (CAS CATO-C4X-130025)
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