3-(2-Chloro-5-methylpyrimidin-4-yl)benzonitrile CAS 1292317-92-0
| CAS No. | 1292317-92-0 |
| Molecular Formula | C12H8ClN3 |
| Molecular Weight | 229.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-(2-Chloro-5-methylpyrimidin-4-yl)benzonitrile (CAS 1292317-92-0), molecular formula C12H8ClN3 and molecular weight 229.67 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, 3-(2-Chloro-5-methylpyrimidin-4-yl)benzonitrile is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 229.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8ClN3 |
| Molecular Weight | 229.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 4-Chloro-2-phenylpyrazolo[1,5-a]pyrazine (CAS 1019164-34-1)
- 5-Chloro-2-phenylpyrazolo[1,5-a]pyrimidine (CAS 1029720-21-5)
- 3-(4-Chloro-2-pyrimidinyl)-1H-Indole (CAS 1146080-35-4)
- 5-Chloro-2-phenyl-2H-benzo[d][1,2,3]triazole (CAS 118416-54-9)
- 2-(6-Chloro-[3,3'-bipyridin]-4-yl)acetonitrile (CAS 1227494-38-3)
- 2-(6-Chloro-[3,4'-bipyridin]-4-yl)acetonitrile (CAS 1227516-46-2)
- 2-(6-Chloro-[2,4'-bipyridin]-5-yl)acetonitrile (CAS 1227516-69-9)
- 2-(2-Chloro-[3,4'-bipyridin]-4-yl)acetonitrile (CAS 1227587-79-2)
Recommended Standards
- 3-(2-Chloro-6-methylpyrimidin-4-yl)benzonitrile (CAS 1292317-91-9)
- 3-(6-Chloropyridazin-3-yl)-1H-indole (CAS 129287-26-9)
- 6-Chloro-3-phenyl-[1,2,4]triazolo[4,3-a]pyridine (CAS 1258542-89-0)
- 4-((3-Chloropyridin-2-yl)amino)benzonitrile (CAS 1313869-86-1)
- [Ru(p-cymene)(O-tBuPPBS)Cl] (CAS 1264657-89-7)
- 3-Isopropyl-5-methyl-1H-indazole (CAS 1415740-53-2)
- N-(3-Chloro-2-methylphenyl)-1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide (CAS 899357-78-9)
- 5-Chloro-4-oxopentanoic acid (CAS 60254-71-9)
- 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)-pyridine-2-carbonitrile (CAS 1823182-91-7)
- 2-butyl-1H-1,3-benzodiazol-5-amine dihydrochloride (CAS 1197821-90-1)
- (S)-Tolterodine (CAS 124937-53-7)
- (R)-2-Hydroxysuccinic Acid Methyl Ester (CAS 83540-94-7)
- 2-(4-Chloro-6-fluoropyridin-3-yl)ethan-1-amine (CAS 1393554-89-6)
- [α-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226159)
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