Levocetirizine Impurity 35 CAS 130018-76-7
| CAS No. | 130018-76-7 |
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | 388.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Levocetirizine Impurity 35 (CAS 130018-76-7, C21H25ClN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Levocetirizine Impurity 35 (C21H25ClN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | 388.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Levocetirizine Standards
- Levocetirizine Impurity 80 (CAS 1232460-31-9)
- Levocetirizine Impurity 68 (CAS CATO-C4X-108368)
- Levocetirizine Impurity 42 (CAS CATO-C4X-108342)
- Levocetirizine Impurity 8 (CAS 83881-46-3)
- Levocetirizine Impurity 44 (CAS 442863-80-1)
- Levocetirizine Impurity 70 (CAS CATO-C4X-108370)
- Levocetirizine Impurity 53 (CAS CATO-C4X-108353)
- Levocetirizine Impurity 11 (CAS 246870-46-2)
Recommended Standards
- Cetirizine EP Impurity C (CAS 83881-59-8)
- Purvalanol A (CAS 212844-53-6)
- Trazodone impurity 62 (CAS CATO-C4X-177262)
- Methyl 4-chloro-2,6-bis(phenylthio)pyrimidine-5-carboxylate (CAS 87847-25-4)
- Fasudil Impurity 45 (CAS CATO-C4X-136545)
- Lifitegrast Impurity 113 (CAS CATO-C4X-2409113)
- Momelotinib impurity 15 (CAS CATO-C4X-337715)
- 4-Bromo-1-hexyl-1h-pyrazol-3-amine (CAS 1282752-36-6)
- N-(4-fluorophenyl)pyrrolidin-3-amine (CAS 886506-05-4)
- 2-(4-Chlorophenyl)-1-((2,4-dichlorobenzyl)oxy)-1H-imidazo[4,5-b]pyridine (CAS 339010-05-8)
- Benz[a]anthracene-7-acetonitrile-13C2 (CAS 1794751-97-5)
- (1S,2R,4R)-Bicyclo[2.2.1]heptan-2-amine hydrochloride (CAS 121055-08-1)
- 2-Amino-5(6)-[α-hydroxybenzyl]benzimidazole (CAS 75501-05-2)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
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