(5s)-5-(Difluoromethyl)pyrrolidin-2-one CAS 1303889-84-0
| CAS No. | 1303889-84-0 |
| Molecular Formula | C5H7F2NO |
| Molecular Weight | 135.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (5s)-5-(Difluoromethyl)pyrrolidin-2-one is closely related to an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(5s)-5-(Difluoromethyl)pyrrolidin-2-one (CAS 1303889-84-0), molecular formula C5H7F2NO and molecular weight 135.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (5s)-5-(Difluoromethyl)pyrrolidin-2-one (C5H7F2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (5s)-5-(Difluoromethyl)pyrrolidin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H7F2NO |
| Molecular Weight | 135.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related s Standards
- 4-(Difluoromethyl)pyrrolidin-2-one (CAS 1803589-29-8)
- (R)-5-(Difluoromethyl)pyrrolidin-2-one (CAS 2446501-35-3)
- 5-(Difluoromethyl)pyrrolidin-2-one (CAS 70994-03-5)
- 2-(Difluoromethyl)thiazole (CAS 2149601-66-9)
- 5-(difluoromethyl)-1,3,4-oxadiazol-2-amine (CAS 1597679-65-6)
- 2-(Difluoromethyl)pyridine (CAS 114468-01-8)
- 2-(Difluoromethyl)piperidine (CAS 1255859-32-5)
- 4-(Difluoromethyl)piperidine Hydrochloride (CAS 1283717-58-7)
Recommended Standards
- 3,3-difluoropiperidin-4-one (CAS 1283720-75-1)
- 5,5-Difluoropiperidin-3-one (CAS 1304192-58-2)
- 2,2-Difluoro-1-Methylcyclopropanecarboxamide (CAS 128230-75-1)
- 3-(2,2-Difluoroethoxy)propanenitrile (CAS 1309602-19-4)
- (S)-3-(5-Oxo-1-phenyl-2-thioxoimidazolidin-4-yl)propanamide (CAS 29588-05-4)
- 2-Acetyl-5-oxo-hexanoic Acid Methyl Ester (CAS 35490-04-1)
- Ethyl 1-Piperazine-d (CAS 1219795-32-0)
- 3-(2,3-Dichlorophenoxy)propan-1-amine (CAS 1017206-42-6)
- 4-bromo-6-methyl-1H-pyrazolo[3,4-c]pyridin-7-one (CAS 1446236-51-6)
- N-(2,5-Difluorobenzyl)-1-(1-isobutyl-1H-pyrazol-4-yl)methanamine hydrochloride (CAS 1856067-79-2)
- (S)-2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetic acid (CAS 1380792-92-6)
- 2-(2,3-Dimethylphenoxy)acetohydrazide (CAS 134432-60-3)
- 1,2-Epoxycyclooctane (CAS 286-62-4)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
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