Ziprasidone EP Impurity D CAS 1303996-68-0
| CAS No. | 1303996-68-0 |
| Molecular Formula | C42H40Cl2N8O3S2 |
| Molecular Weight | 839.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ziprasidone EP Impurity D.
As a process- or degradation-related impurity, Ziprasidone EP Impurity D (CAS 1303996-68-0, C42H40Cl2N8O3S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C42H40Cl2N8O3S2, Ziprasidone EP Impurity D contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 839.85 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ziprasidone EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C42H40Cl2N8O3S2 |
| Molecular Weight | 839.85 g/mol |
| Purity | >80% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 26.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 2 |
Related Ziprasidone Standards
- Ziprasidone EP Impurity E (CAS 1159977-04-4)
- Ziprasidone Impurity 72 (CAS CATO-C4X-124072)
- Ziprasidone Impurity 74 (CAS CATO-C4X-124074)
- Ziprasidone impurity 56 (CAS CATO-C4X-124056)
- Ziprasidone impurity 57 (CAS CATO-C4X-124057)
- Ziprasidone impurity 58 (CAS CATO-C4X-124058)
- Ziprasidone Impurity 65 (CAS CATO-C4X-124065)
- Ziprasidone Impurity 70 (CAS CATO-C4X-124070)
Recommended Standards
- (4-Chlorophenyl)[2-[4-(1,1-dimethylethyl)phenyl]-2-oxoethyl][1,2-phenylenebis[diphenylphosphine-κP]]palladium (CAS 727722-25-0)
- N-[(11bS)-2,6-Di-9-anthracenyl-8,9,10,11,12,13,14,15-octahydro-8-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-1,1,1-trifluoromethanesulfonamide (CAS 1227374-64-2)
- (3-Chlorophenyl)[2-[4-(1,1-dimethylethyl)phenyl]-2-oxoethyl][1,2-phenylenebis[diphenylphosphine-κP]]palladium (CAS 727722-26-1)
- N-[(11bR)-2,6-Di-9-anthracenyl-8,9,10,11,12,13,14,15-octahydro-8-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-1,1,1-trifluoromethanesulfonamide (CAS 1227374-65-3)
- Cefotaxime Impurity 69 (CAS CATO-C4X-120169)
- Dasatinib Impurity 40 (CAS 103-76-4)
- Linezolid Impurity 45 (CAS 168828-81-7)
- 1-(Bromomethyl)-1-((1,1,1-trifluoropropan-2-yl)oxy)cyclohexane (CAS 1503497-68-4)
- 2,6-Dibromoquinazolin-8-ol (CAS 953040-59-0)
- (3-Amino-pyrrolidin-1-yl)-acetic acid dihydrochloride (CAS 1187926-97-1)
- 5,6-difluoro-1H-indole-7-carboxylic acid (CAS 875305-88-7)
- Pentoxyverine Impurity 22 (CAS 13877-99-1)
- 2-Chloro-3-nitro-5,6,7,8-tetrahydroquinoline (CAS 187243-00-1)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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