6-(3-(Trifluoromethyl)phenyl)-1H-imidazo[1,2-b]pyrazole CAS 130598-75-3
| CAS No. | 130598-75-3 |
| Molecular Formula | C12H8F3N3 |
| Molecular Weight | 251.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-(3-(Trifluoromethyl)phenyl)-1H-imidazo[1,2-b]pyrazole (CAS 130598-75-3), molecular formula C12H8F3N3 and molecular weight 251.21 g/mol, is a CATO reference standard with documented purity and traceability.
6-(3-(Trifluoromethyl)phenyl)-1H-imidazo[1,2-b]pyrazole (C12H8F3N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 6-(3-(Trifluoromethyl)phenyl)-1H-imidazo[1,2-b]pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8F3N3 |
| Molecular Weight | 251.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 6-(4-(Trifluoromethyl)phenyl)-1H-imidazo[1,2-b]pyrazole (CAS 130598-74-2)
- (4-Trifluoromethyl-2H-pyrazol-3-yl)-carbamic acid tert-butyl ester (CAS 2355385-20-3)
- 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl propylcarbamate (CAS 477713-72-7)
- 2-(1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)benzonitrile (CAS 910037-17-1)
- 3-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzonitrile (CAS 209958-67-8)
- 8-Methyl-5-(3-(trifluoromethyl)-3H-diazirin-3-yl)quinoline (CAS 2231672-99-2)
- 4-(4-(Trifluoromethyl)phenyl)picolinaldehyde (CAS 1005189-47-8)
- 6-(2-(Trifluoromethyl)phenyl)picolinaldehyde (CAS 112432-96-9)
Recommended Standards
- 2,2,2-trifluoroethyl 1-isopropyl-1H-pyrazol-5-ylcarbamate (CAS 1334023-30-1)
- ethyl 5-amino-2-methyl-1-(2,2,2-trifluoroethyl)-1H-imidazole-4-carboxylate (CAS 1285486-92-1)
- 2,2,2-trifluoroethyl 1-propyl-1H-pyrazol-5-ylcarbamate (CAS 1334025-02-3)
- 5-((4-Fluoro-2-nitrophenoxy)methyl)-1-methyl-1H-pyrazole (CAS 1245823-45-3)
- Methyl 2-(2-(3-methoxyphenoxy)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (CAS 333766-44-2)
- CAS 2483831-70-3 (CAS 2483831-70-3)
- n-((5-Methyl-1,2,4-oxadiazol-3-yl)methyl)-N-(pyrrolidin-3-yl)acetamide (CAS 1421601-33-3)
- Rotigotine Impurity 29 (CAS CATO-C4X-192729)
- 3-Chloro-N-(3-ethoxypropyl)-5-(trifluoromethyl)-2-pyridinamine (CAS 1040309-94-1)
- n-(4-Bromophenyl)-5-methylfuran-2-carboxamide (CAS 540755-09-7)
- 1-(2-Methoxyethyl)guanidine acetate (CAS 1609401-38-8)
- Boc-Ala-D-Glu(OBzl)-OH (CAS 53759-36-7)
- 5-fluoro-1-phenyl-1H-pyrazole-4-carboxylic acid (CAS 265986-57-0)
- Tirzepatide Impurity 59 (CAS CATO-C4X-324059)
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