Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate CAS 130754-19-7
| CAS No. | 130754-19-7 |
| Molecular Formula | C10H9ClF2O2 |
| Molecular Weight | 234.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate.
Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate (CAS 130754-19-7), molecular formula C10H9ClF2O2 and molecular weight 234.63 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate (C10H9ClF2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Ethyl 4-Chloro-alpha,alpha-difluorophenylacetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9ClF2O2 |
| Molecular Weight | 234.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
Related Ethyl Standards
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- Methyl 5-chloropicolinate hydrochloride (CAS 1956318-06-1)
- 2,4-Dibromonicotinaldehyde (CAS 128071-91-0)
- 1H,2H,3H,4H,5H,6H-azepino[4,3-b]indole hydrochloride (CAS 1803607-15-9)
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- Valsartan Impurity 68 (CAS CATO-C4X-105768)
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