6-Chloro-2-cyclopropyl-5-fluoropyrimidin-4-amine CAS 1311275-34-9
| CAS No. | 1311275-34-9 |
| Molecular Formula | C7H7ClFN3 |
| Molecular Weight | 187.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 187.60 g/mol gives 6-Chloro-2-cyclopropyl-5-fluoropyrimidin-4-amine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
6-Chloro-2-cyclopropyl-5-fluoropyrimidin-4-amine (CAS 1311275-34-9), molecular formula C7H7ClFN3 and molecular weight 187.60 g/mol, is a CATO reference standard with documented purity and traceability.
6-Chloro-2-cyclopropyl-5-fluoropyrimidin-4-amine (C7H7ClFN3) contains a nitrile group, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7ClFN3 |
| Molecular Weight | 187.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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- 5-Chloro-2-fluoro-N-methylbenzamide (CAS 1223412-83-6)
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Recommended Standards
- 4-Chloro-[1,3]dioxolo[4,5-c]pyridine-2-thione (CAS 1261584-77-3)
- 2-Chloro-6-fluoro-N-methylbenzamide (CAS 1342977-40-5)
- 1-(4-Amino-2-chloro-5-fluorophenyl)ethanone (CAS 1260657-47-3)
- 2-Amino-1-(2-chloro-4-fluorophenyl)ethan-1-one (CAS 1343003-67-7)
- Sodium 4-fluoro-1-methyl-1h-benzo[d]imidazole-2-carboxylate (CAS 2197052-77-8)
- Potassium tetrahydrofuran-3-trifluoroborate (CAS 1391850-45-5)
- 3-(1-Hydroxy-2,2,2-trifluoroethyl)-1-(trifluoroacetyl)pyrrolidine (CAS 1159981-93-7)
- 2-(2-Amino-5-methylphenyl)acetic acid (CAS 37777-65-4)
- Propyl 3-(4h-1,2,4-triazol-3-yl)propanoate (CAS 1384803-10-4)
- 1-(4-Bromo-2-(difluoromethyl)phenyl)ethan-1-one (CAS 2386658-14-4)
- Ethyl 2-(5-(trifluoromethyl)pyridin-2-yl)acetate (CAS 757971-25-8)
- n1-Cyclopropyl-n3-ethyl-n3-methylpropane-1,3-diamine (CAS 1179889-20-3)
- Clozapine-D4 (CAS 204395-52-8)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
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