Nadifloxacin Impurity 1 CAS 131190-82-4
| CAS No. | 131190-82-4 |
| Molecular Formula | C10H6BrF2N |
| Molecular Weight | 258.06 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Nadifloxacin Impurity 1 (CAS 131190-82-4, C10H6BrF2N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Nadifloxacin Impurity 1 (C10H6BrF2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 258.06 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Nadifloxacin Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6BrF2N |
| Molecular Weight | 258.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Nadifloxacin Standards
- Nadifloxacin Impurity 15 (CAS 64695-81-4)
- Nadifloxacin isomer 1 (CAS 87488-29-7)
- Nadifloxacin Impurity A (CAS 80076-47-7)
- Nadifloxacin Impurity 6 (CAS 87-13-8)
- Nadifloxacin Impurity 2 (CAS 80076-46-6)
- Nadifloxacin Impurity 3 (CAS 80076-50-2)
- Nadifloxacin Impurity 14 (CAS 458-11-7)
- Nadifloxacin isomer 2 (CAS 130539-72-9)
Recommended Standards
- Lamotrigine EP Impurity D (CAS 661463-79-2)
- 3-(2,4-Dichlorophenyl)-1,1,1-trifluoropropan-2-amine (CAS 1004286-26-3)
- Ziprasidone impurity 49 (CAS CATO-C4X-124049)
- 2-Bromo-1-(3-methyl-4-nitrophenyl)ethanone (CAS 1010384-55-0)
- Valsartan Impurity 124 (CAS CATO-C4X-1057124)
- Naratriptan Impurity 2 (CAS 2144776-32-7)
- Selumetinib Impurity 19 (CAS CATO-C4X-305319)
- N-(4-(2-chlorophenoxy)phenyl)acetamide (CAS 915879-09-3)
- (4-(Furan-2-carbonyl)piperazin-1-yl)(p-tolyl)methanone (CAS 694473-64-8)
- 3-(Bromomethyl)-2-(2-chlorophenyl)-5,6-difluoroquinoxaline (CAS 1065481-84-6)
- 5-Bromo-7-methyl-2,3-dihydro-1,3-benzoxazol-2-one (CAS 1268153-81-6)
- (3AS,4R,5aR,9aR,9bS)-2,2,8,8-tetramethylhexahydro-[1,3]dioxolo[4',5':4,5]pyrano[3,2-d][1,3]dioxin-4-ol (CAS 130495-48-6)
- (2-Amino-4-chlorophenyl)(cyclopentyl)methanone (CAS 959137-40-7)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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