Erlotinib Impurity 57 CAS 1312937-41-9
| CAS No. | 1312937-41-9 |
| Molecular Formula | C15H20N2O5 |
| Molecular Weight | 308.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 308.33 g/mol gives Erlotinib Impurity 57 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Erlotinib Impurity 57 (CAS 1312937-41-9, C15H20N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Erlotinib Impurity 57 (C15H20N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Erlotinib Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H20N2O5 |
| Molecular Weight | 308.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Related Erlotinib Standards
- Erlotinib Impurity 77 (CAS CATO-C4X-106977)
- Erlotinib Impurity 64 (CAS CATO-C4X-106964)
- Erlotinib Impurity 13 (CAS 183322-18-1)
- Erlotinib Impurity 54 (CAS CATO-C4X-106954)
- Erlotinib Impurity 80 (CAS 2518426-66-7)
- Erlotinib Impurity 62 (CAS CATO-C4X-106962)
- Erlotinib Impurity 63 (CAS CATO-C4X-106963)
- Erlotinib Impurity 11 (CAS 183322-19-2)
Recommended Standards
- Z-D-Arg-OH (CAS 6382-93-0)
- Z-Arg-OH (CAS 1234-35-1)
- Palbociclib Impurity 111 (CAS 571189-16-7)
- (R)-methyl 2-((R)-2-(benzyloxycarbonylamino)propanamido)propanoate 19914-26-2 Z-D-Ala-D-Ala-OMe (CAS 19914-26-2)
- Dimetindene EP Impurity I (CAS 151562-10-6)
- Ibrutinib Impurity 80 (CAS 109384-19-2)
- Albendazole impurity 31 (CAS CATO-C4X-153531)
- 3-Chloro-2-(2-ethylphenoxy)aniline (CAS 946714-69-8)
- 2,4,6-Tris(cyclohexyloxy)-1,3,5,2,4,6-trioxatriborinane (CAS 1172-69-6)
- 2-(Iodomethyl)-5-(trifluoromethyl)benzo[d]thiazole (CAS 1355612-99-5)
- 5-(3,4-Dichlorophenyl)-1,2,4-oxadiazole-3-carboxylic acid (CAS 1339920-66-9)
- 2,2,2-trifluoroethyl methylcarbamate (CAS 878218-01-0)
- 3-Amino-2,2-difluoropropan-1-ol (CAS 155310-11-5)
- Acetyl-Exenatide trifluoroacetate salt (CAS 305815-28-5)
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