Erlotinib Impurity 77 CAS CATO-C4X-106977
| CAS No. | CATO-C4X-106977 |
| Molecular Formula | C15H20N2O5 |
| Molecular Weight | 308.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Erlotinib Impurity 77 (CAS CATO-C4X-106977, C15H20N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Erlotinib Impurity 77 (C15H20N2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H20N2O5 |
| Molecular Weight | 308.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Erlotinib Standards
- Erlotinib Impurity 57 (CAS 1312937-41-9)
- Erlotinib Impurity 64 (CAS CATO-C4X-106964)
- Erlotinib Impurity 13 (CAS 183322-18-1)
- Erlotinib Impurity 54 (CAS CATO-C4X-106954)
- Erlotinib Impurity 80 (CAS 2518426-66-7)
- Erlotinib Impurity 62 (CAS CATO-C4X-106962)
- Erlotinib Impurity 63 (CAS CATO-C4X-106963)
- Erlotinib Impurity 11 (CAS 183322-19-2)
Recommended Standards
- Palbociclib Impurity 111 (CAS 571189-16-7)
- Z-D-Arg-OH (CAS 6382-93-0)
- Palbociclib Impurity 150 (CAS CATO-C4X-1125150)
- Z-Arg-OH (CAS 1234-35-1)
- Carbazochrome Impurity 52 (CAS CATO-C4X-229152)
- Doxofylline Impurity 49 (CAS CATO-C4X-151349)
- Paricalcitol Impurity 29 (CAS 139356-37-9)
- 6-Thiomorpholinonicotinic acid (CAS 1042634-50-3)
- (4-Bromophenyl)(imino)(trifluoromethyl)-l6-sulfanone (CAS 1421133-03-0)
- Sodium (3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate dihydrate (CAS 58917-14-9)
- 2-(3-Methoxyphenyl)-3-phenylpropanoic acid (CAS 3160-94-9)
- Hex-4-enoic acid (CAS 35194-36-6)
- 2,6-Di-tert-butylpyridine hexafluorophosphate (CAS 1017592-16-3)
- Tirzepatide Impurity 50 (CAS CATO-C4X-324050)
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