Flumazenil EP Impurity B CAS 131666-45-0
| CAS No. | 131666-45-0 |
| Molecular Formula | C15H15N3O4 |
| Molecular Weight | 301.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Flumazenil EP Impurity B (CAS 131666-45-0, C15H15N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C15H15N3O4, Flumazenil EP Impurity B contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 301.30 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flumazenil EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H15N3O4 |
| Molecular Weight | 301.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 3 |
Related Flumazenil Standards
- Flumazenil Impurity 12 (CAS CATO-C4X-143212)
- Flumazenil-D5 (CAS 2700278-14-2)
- Flumazenil (CAS 78755-81-4)
- Flumazenil Impurity 21 (CAS CATO-C4X-143221)
- Flumazenil Impurity 14 (CAS 1291916-17-0)
- Flumazenil Impurity 15 (CAS CATO-C4X-143215)
- Flumazenil Impurity 17 (CAS CATO-C4X-143217)
- Flumazenil (N-[11C]Methyl) EP Impurity A (CAS 79089-72-8)
Recommended Standards
- Apixaban Impurity 118 (CAS 2818923-97-4)
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- Letrozole Impurity 36 (CAS CATO-C4X-182936)
- Iguratimod Impurity 46 (CAS CATO-C4X-182646)
- Atogepant Impurity 41 (CAS CATO-C4X-328541)
- Atrasentan Impurity 47 (CAS 1059052-54-8)
- (1R,5S)-Bicyclo[3.1.0]hexan-2-one (CAS 58001-78-8)
- 6-Bromo-5-cyclopropoxy-N-methylpyridin-2-amine (CAS 1243312-59-5)
- 4-((4-Fluorophenyl)thio)butan-1-amine (CAS 1082432-79-8)
- (4R)-2-(3-methylthiophen-2-yl)thiazolidine-4-carboxylic acid (CAS 219709-73-6)
- 4-Mercaptocyclohexan-1-ol (CAS 89534-17-8)
- 2-(1,1-Difluoropropyl)-1H-pyrrole (CAS 1186194-53-5)
- Peptide Impurity 26 (CAS 1350456-66-4)
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