(E)-Methyl 2-(2-((6-(2-carbamoylphenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate CAS 131860-82-7
| CAS No. | 131860-82-7 |
| Molecular Formula | C22H19N3O6 |
| Molecular Weight | 421.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-Methyl 2-(2-((6-(2-carbamoylphenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate (CAS 131860-82-7), molecular formula C22H19N3O6 and molecular weight 421.40 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-Methyl 2-(2-((6-(2-carbamoylphenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate (C22H19N3O6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H19N3O6 |
| Molecular Weight | 421.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Nitrogen Atoms | 3 |
Recommended Standards
- 3,3′-[2,6-Pyridinediylbis(5,2-oxazolediyl)]bis[benzaldehyde] (CAS 1224193-67-2)
- 1-((5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)methyl)-3-(3-(thiophen-3-yl)-1,2,4-oxadiazol-5-yl)pyridin-2(1H)-one (CAS 1396859-49-6)
- Dolutegravir Impurity 44 (CAS 2518311-04-9)
- Vonoprazan Impurity 296 (CAS CATO-C4X-1020296)
- N-Ethyl-N-(2-pyrrolidinylmethyl)cyclohexanaminedihydrochloride (CAS 1219964-36-9)
- 2-Amino-1-((S)-2-(methoxymethyl)pyrrolidin-1-yl)-3-methylbutan-1-one (CAS 1354029-42-7)
- 4-Chloro-2-iodobenzo[d]oxazole (CAS 1804187-07-2)
- 5-Chloro-2-(4-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine (CAS 866050-57-9)
- benzyl 4-(benzyloxycarbonylamino)-2,7-diazaspiro[4.4]nonane-2-carboxylate (CAS 2306275-96-5)
- 3-(2-Fluorophenyl)azetidin-3-ol hydrochloride (CAS 2287309-85-5)
- 1,2,4,5-Benzenetetracarboxylic Acid-d6 (CAS 344298-79-9)
- N-(3-bromo-4-methylphenyl)-1-phenylcyclopentane-1-carboxamide (CAS 1024052-51-4)
- Aqua(tetraphenylporphyrinato)magnesium (CAS 24968-22-7)
- Liraglutide Impurity 30 (CAS CATO-C4X-199230)
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