(E)-Methyl 2-(2-((6-(4-chloro-2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate CAS 131860-80-5
| CAS No. | 131860-80-5 |
| Molecular Formula | C22H16ClN3O5 |
| Molecular Weight | 437.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-Methyl 2-(2-((6-(4-chloro-2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate (C22H16ClN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies (E)-Methyl 2-(2-((6-(4-chloro-2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate (CAS 131860-80-5), a certified reference material (molecular formula C22H16ClN3O5, MW 437.83 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-Methyl 2-(2-((6-(4-chloro-2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H16ClN3O5 |
| Molecular Weight | 437.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- Tris(decyl)amine (CAS 1070-01-5)
- 3-Chloro-2-{[7-(4-methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]sulfanyl}-5-(trifluoromethyl)pyridine (CAS 338775-15-8)
- Sitafloxacin Impurity 38 (CAS CATO-C4X-115538)
- Pomalidomide-acetamido-O-PEG1-C2-Cl (CAS 2162120-92-3)
- 1,3(d5)-dipentadecanoyl-2-(9z-octadecenoyl)-glycerol 944709-24-4 (CAS 944709-24-4)
- 3-Aminononan-2-ol (CAS 75166-64-2)
- Tert-butyl 4-(2-chloropropanoyl)piperazine-1-carboxylate (CAS 1181803-80-4)
- n-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]-2-(2,4,6-trimethylphenoxy)acetamide (CAS 752219-52-6)
- tert-Butyl (3-chloro-4-(hydroxymethyl)phenyl)carbamate (CAS 180150-16-7)
- 5-(1-Hydroxyethyl)-1H-pyrazole-3-carboxylic acid (CAS 1401584-94-8)
- H-D-Val-OtBu · HCl (CAS 104944-18-5)
- 4-Bromo-3-cyanobenzylamine (CAS 1261791-04-1)
- 1-(3-Bromo-6-methoxypyridin-2-yl)ethanone (CAS 1256806-19-5)
- MCH-Gene-Overprinted-Polypeptide-14 (rat) (H-4746.0500) (CAS 182917-44-8)
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