Lansoprazole EP Impurity B/USP Impurity A CAS 131926-99-3
| CAS No. | 131926-99-3 |
| Molecular Formula | C16H14F3N3O3S |
| Molecular Weight | 385.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Lansoprazole EP Impurity B/USP Impurity A (CAS 131926-99-3, C16H14F3N3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H14F3N3O3S, Lansoprazole EP Impurity B/USP Impurity A contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 385.36 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14F3N3O3S |
| Molecular Weight | 385.36 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Lansoprazole Standards
- Lansoprazole EP Impurity A (CAS 213476-12-1)
- Lansoprazole EP Impurity A (CAS CATO-C4X-16121)
- Lansoprazole EP Impurity B-D4 (CAS 1184999-77-6)
- Lansoprazole-d4 N-Oxide (CAS 1346604-20-3)
- Lansoprazole-d4 (CAS 934294-22-1)
- Lansoprazole (CAS 103577-45-3)
- Lansoprazole Impurity 15 (CAS 163119-30-0)
- (S)-Lansoprazole (CAS 138530-95-7)
Recommended Standards
- 5-Hydroxy Lansoprazole (CAS 131926-98-2)
- Dimethyl 5-(4-(trifluoromethyl)phenyl)-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate (CAS 337920-98-6)
- Diethyl (((2S,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl)methyl)phosphonate (CAS 90012-88-7)
- Sarafloxacin (CAS 98105-99-8)
- Mitiglinide Impurity 6 (CAS CATO-C4X-11616)
- Fluticasone Impurity 104 (CAS CATO-C4X-1650104)
- Sarpogrelate Impurity 14 (CAS CATO-C4X-291314)
- 4-(Bromomethyl)-2-chloro-6-fluoropyridine (CAS 1227603-89-5)
- 4,6-Dichlorobenzo[d]thiazole, 97% (CAS 854059-32-8)
- N1-(3-Acetamidophenyl)-N2-((1-methylpiperidin-4-yl)methyl)oxalamide (CAS 952975-04-1)
- 5-[7-(5-Amino-1,3,4-thiadiazol-2-yl)heptyl]-1,3,4-thiadiazol-2-ylamine oxalate (CAS 1177312-67-2)
- Valdecoxib Impurity 1 (CAS CATO-C4X-14511)
- ACETIC ACID, DICYANO-, METHYL ESTER (CAS 6625-70-3)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
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