2-Chloro-7-fluoro-3-methylquinoline CAS 132118-48-0
| CAS No. | 132118-48-0 |
| Molecular Formula | C10H17ClFN |
| Molecular Weight | 205.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-7-fluoro-3-methylquinoline is closely related to a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Chloro-7-fluoro-3-methylquinoline (CAS 132118-48-0), molecular formula C10H17ClFN and molecular weight 205.70 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrile group, fluorine/chlorine substitution, 2-Chloro-7-fluoro-3-methylquinoline is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 205.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H17ClFN |
| Molecular Weight | 205.70 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- (2R)-2-(3-chloro-4-fluorophenyl)pyrrolidine (CAS 1241678-96-5)
- 6-chloro-7-fluoro-2-methyl-quinoline (CAS 1491163-25-7)
- 4-Chloro-7-fluoro-2-methylquinoline (CAS 18529-04-9)
- 4-Chloro-8-fluoro-2-methylquinoline (CAS 18615-59-3)
- 2-chloro-1,3-benzothiazin-4-one (CAS 7742-71-4)
- 4-chloro-6-fluoro-7-methyl-quinoline (CAS 2216746-75-5)
- 4-chloro-7-methoxypyrido[3,2-d]pyrimidine (CAS 1256811-43-4)
- 4-chloro-8-methoxy-pyrido[3,4-d]pyrimidine (CAS 1260178-67-3)
Recommended Standards
- 3-(4-Chlorobutyl)-4-methylthiazol-2(3h)-one (CAS 1250185-05-7)
- 1,2-benzothiazole-3-carbonyl chloride (CAS 145759-64-4)
- 2-(5-Chlorothiophen-2-yl)-2-ethoxyethan-1-amine (CAS 1250085-07-4)
- 4-(Chloromethyl)-2-(1-ethoxyethyl)-1,3-thiazole (CAS 1247625-25-7)
- 2-Methoxy-5-propylbenzaldehyde (CAS 145742-54-7)
- Sodium 2-[3-(hydroxymethyl)-1H-indol-1-yl]acetate (CAS 1803604-62-7)
- 6-Hydroxy-3-methyl-5-phenyl-1-(p-tolyl)pyridazin-4(1H)-one (CAS 89314-17-0)
- tert-Butyl 3-(3-bromophenyl)-3-oxopropanoate (CAS 1071767-18-4)
- Muscarine (CAS 300-54-9)
- 6-Methoxyquinoline-5-carbaldehyde (CAS 82060-64-8)
- Letrozole (CAS 112809-51-5)
- 2-(2-((tert-Butoxycarbonyl)(methyl)amino)-N-methylacetamido)acetic acid (CAS 56612-14-7)
- 6-Bromo-3H-imidazo[4,5-b]pyridine 4-oxide (CAS 83472-57-5)
- Tirzepatide Impurity 58 (CAS CATO-C4X-324058)
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