Isosorbide Dinitrate Impurity 9 CAS 13241-36-6
| CAS No. | 13241-36-6 |
| Molecular Formula | C6H6O4 |
| Molecular Weight | 142.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Isosorbide Dinitrate Impurity 9.
As a process- or degradation-related impurity, Isosorbide Dinitrate Impurity 9 (CAS 13241-36-6, C6H6O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Isosorbide Dinitrate Impurity 9 (C6H6O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6O4 |
| Molecular Weight | 142.11 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
Related Isosorbide Standards
- Isosorbide (CAS 652-67-5)
- Isosorbide Impurity 21 (CAS 28218-55-5)
- Isosorbide Impurity 23 (CAS 45895-44-1)
- Isosorbide Impurity 24 (CAS 52485-66-2)
- Isosorbide Dimethyl Ether (CAS 5306-85-4)
- Isosorbide Dinitrate 19 (CAS 1932354-37-4)
- Isosorbide Dinitrate Impurity 20 (CAS 175220-76-5)
- Isosorbide Dinitrate Impurity 5 (CAS 13042-39-2)
Recommended Standards
- Phloroglucinol impurity 45 (CAS 634-94-6)
- Furfural impurity 4 (CAS CATO-C4X-24884)
- Fluorouracil Impurity 30 (CAS CATO-C4X-164930)
- Furfural impurity 5 (CAS 1103461-95-5)
- Betamethasone Impurity 120 (CAS 82536-56-9)
- Captopril EP Impurity E (CAS 23500-15-4)
- Glibenclamide EP Impurity D (CAS 38160-73-5)
- 1-(4-Fluoro-5-methyl-2-nitrophenyl)-4-(4-methoxybenzenesulfonyl)piperazine (CAS 1262222-56-9)
- N'-(Diphenylmethylidene)-2-(4-methyl-2-nitrophenoxy)acetohydrazide (CAS 341967-97-3)
- 4-(1-Methyl-1h-pyrazol-4-yl)-1,2,3,4-tetrahydroquinoline (CAS 1306603-81-5)
- 4-(5-Chlorobenzo[d]thiazol-2-yl)morpholine (CAS 4466-33-5)
- 4-(1'-Ethyl-3'-methyl-1h,1'h-[3,4'-bipyrazol]-1-yl)aniline (CAS 1006320-07-5)
- 2-Amino-4-(4H-1,2,4-triazol-4-yl)benzoic acid (CAS 915920-19-3)
- Semaglutide impurity 206 (CAS CATO-C4X-2226206)
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