Captopril EP Impurity E CAS 23500-15-4
| CAS No. | 23500-15-4 |
| Molecular Formula | C9H15NO3 |
| Molecular Weight | 185.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Captopril EP Impurity E (CAS 23500-15-4, C9H15NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Captopril EP Impurity E (C9H15NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H15NO3 |
| Molecular Weight | 185.22 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 1 |
Related Captopril Standards
- Captopril Impurity 37(Piracetam Impurity E) (CAS 1249080-59-8)
- Captopril Impurity 26 (CAS 51161-88-7)
- Captopril Impurity 31 (CAS 69570-39-4)
- Captopril Impurity 8 (CAS 74345-73-6)
- Captopril impurity 41 (CAS 74190-08-2)
- Captopril Impurity 35 (CAS 613256-52-3)
- Captopril EP Impurity D (CAS 56970-78-6)
- Captopril EP Impurity G (R-Isomer) (CAS 74431-52-0)
Recommended Standards
- Benidipine Impurity 12 (CAS 76509-17-6)
- Glimepiride Impurity 16 (CAS 247098-17-5)
- Eltrombopag Impurity 68 (CAS 53442-24-3)
- Levetiracetam Impurity 5 (CAS 358629-51-3)
- Famciclovir Impurity 25 (CAS CATO-C4X-164225)
- Levothyroxine Impurity 43 (CAS 854646-83-6)
- All-Rac-Phytomenadione EP Impurity B (CAS 25486-55-9)
- 1-(3-(4-Bromo-2-fluorophenoxy)propyl)-4-ethylpiperazine (CAS 1704080-79-4)
- Metoclopramide (CAS 364-62-5)
- 2-methyl-2-(2-phenylethyl)pyrrolidine (CAS 1539611-46-5)
- N-Acetyl-L-alanine (CAS 97-69-8)
- 3-(Pyridin-4-ylmethyl)piperidin-3-ol (CAS 1482133-46-9)
- 4-Cyclohex-1-en-1-yl-1H-pyrazol-5-amine (CAS 1257859-00-9)
- Peptide Impurity 27 (CAS 1350456-68-6)
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