4-(2,4-Difluorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid CAS 1326812-48-9
| CAS No. | 1326812-48-9 |
| Molecular Formula | C17H20F2N2O4 |
| Molecular Weight | 354.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(2,4-Difluorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid.
4-(2,4-Difluorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326812-48-9), molecular formula C17H20F2N2O4 and molecular weight 354.35 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(2,4-Difluorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (C17H20F2N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H20F2N2O4 |
| Molecular Weight | 354.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorobenzoyl Standards
- 4-(3,5-Difluorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326808-43-8)
- 4-(3,4-Difluorobenzoyl)-8-ethyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326810-88-1)
- N'-(2,6-difluorobenzoyl)-3-(1H-pyrrol-1-yl)thiophene-2-carbohydrazide (CAS 478062-75-8)
- 4-(2,5-Difluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326809-10-2)
- 4-(3,5-Difluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326812-08-1)
- 4-(2,4-Difluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326813-14-2)
- 4-(3,4-Difluorobenzoyl)-8-propyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326813-21-1)
- 4-(2,5-Difluorobenzoyl)-8-methyl-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326810-44-9)
Recommended Standards
- EPISESAMIN (CAS 133-03-9)
- 7-O-Pivaloyl-genistein (CAS 1346605-04-6)
- (1R,3aS,4R,6aS)-1,4-Bis(benzo[d][1,3]dioxol-5-yl)hexahydrofuro[3,4-c]furan (CAS 13079-95-3)
- Demethyl Curcumin (CAS 149732-51-4)
- 4-Amino-3-(difluoromethyl)-6-methoxypyridin-2-ol (CAS 1806790-39-5)
- 3-Methylbenzo[b]thiophene-2-carbonitrile (CAS 3216-49-7)
- 2-(tert-Butoxy)-3-cyclopropoxy-4-nitropyridine (CAS 1243460-16-3)
- N-Cyclohexyl-N-ethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide HCl (CAS 1219982-56-5)
- Methyl 5-(4-chloro-3-fluorophenyl)-3-methyl-5-oxopentanoate (CAS 1443311-23-6)
- 2-Hydroxythioxanthone (CAS 31696-67-0)
- 4-(7-Chloroquinolin-4-yl)morpholine hydrochloride (CAS 853344-40-8)
- 1-(3,5-Dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione (CAS 1613373-33-3)
- 2-(4-Chlorophenyl)-2,3-dihydroquinazolin-4(1h)-one (CAS 13165-11-2)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
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