(2E)-3-[5-chloro-2-(difluoromethoxy)phenyl]prop-2-enoic acid CAS 1329166-85-9
| CAS No. | 1329166-85-9 |
| Molecular Formula | C10H7ClF2O3 |
| Molecular Weight | 248.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2E)-3-[5-chloro-2-(difluoromethoxy)phenyl]prop-2-enoic acid.
(2E)-3-[5-chloro-2-(difluoromethoxy)phenyl]prop-2-enoic acid (CAS 1329166-85-9) is a high-purity analytical reference standard with the molecular formula C10H7ClF2O3 and a molecular weight of 248.61 g/mol.
(2E)-3-[5-chloro-2-(difluoromethoxy)phenyl]prop-2-enoic acid (C10H7ClF2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (2E)-3-[5-chloro-2-(difluoromethoxy)phenyl]prop-2-enoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7ClF2O3 |
| Molecular Weight | 248.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
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Recommended Standards
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- 4-(tert-Butyl)-2-(tributylstannyl)pyridine (CAS 894769-22-3)
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- 4-Chloro-2,5-dimethyl-6-(1H-pyrazol-1-yl)pyrimidine (CAS 1339677-70-1)
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- [Glu]17-Liraglutide (CAS CATO-C4X-199236)
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