Apalutamide Impurity 6 CAS 1332391-11-3
| CAS No. | 1332391-11-3 |
| Molecular Formula | C20H13F4N5O2S |
| Molecular Weight | 463.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Apalutamide Impurity 6 is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Apalutamide Impurity 6 (CAS 1332391-11-3) is a certified pharmaceutical impurity reference standard with the molecular formula C20H13F4N5O2S and a molecular weight of 463.41 g/mol.
Apalutamide Impurity 6 (C20H13F4N5O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Apalutamide Impurity 6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H13F4N5O2S |
| Molecular Weight | 463.41 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Apalutamide Standards
- Apalutamide Impurity 69 (CAS CATO-C4X-274969)
- Apalutamide Acid (CAS 1332391-04-4)
- Apalutamide Impurity 11 (CAS 1332391-92-0)
- Apalutamide Impurity 54 (CAS 1332389-57-7)
- Apalutamide Impurity 101 (CAS CATO-C4X-2749101)
- Apalutamide Impurity 75 (CAS CATO-C4X-274975)
- Apalutamide impurity 84 (CAS CATO-C4X-274984)
- Apalutamide Impurity 56 (CAS CATO-C4X-274956)
Recommended Standards
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Why CATO?
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