1-(2,4-Difluorophenyl)pyrrolidine CAS 1334499-91-0
| CAS No. | 1334499-91-0 |
| Molecular Formula | C10H11F2N |
| Molecular Weight | 183.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(2,4-Difluorophenyl)pyrrolidine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(2,4-Difluorophenyl)pyrrolidine (CAS 1334499-91-0), molecular formula C10H11F2N and molecular weight 183.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(2,4-Difluorophenyl)pyrrolidine (C10H11F2N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11F2N |
| Molecular Weight | 183.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 2-(2,6-Difluorophenyl)pyrrolidine (CAS 1016529-46-6)
- 3-(2,4-Difluorophenyl)pyrrolidine (CAS 1092108-80-9)
- (S)-1-(2,3-difluorophenyl)but-3-en-1-amine (CAS 1181817-73-1)
- (S)-1-(3,5-difluorophenyl)but-3-en-1-amine (CAS 1181817-76-4)
- 1-(2,6-Difluorophenyl)cyclopropanemethanamine (CAS 1216908-25-6)
- (2S)-2-(2,5-DIFLUOROPHENYL)PYRROLIDINE (CAS 1217630-38-0)
- (S)-2-(3,5-Difluorophenyl)pyrrolidine (CAS 1217664-59-9)
- (S)-2-(2,4-difluorophenyl)pyrrolidine (CAS 1217667-72-5)
Recommended Standards
- Ethyl 4-isopropylisoxazole-3-carboxylate (CAS 1332635-53-6)
- (R)-3-(3,4-difluorophenyl)pyrrolidine (CAS 1335886-75-3)
- Acetyl Isoniazid-d4 (CAS 1330169-81-7)
- (S)-3-(3,4-difluorophenyl)pyrrolidine (CAS 1335947-25-5)
- Methyl (R)-3-amino-3-(2-fluoro-4-hydroxyphenyl)propanoate (CAS 1212825-90-5)
- N-(5-Oxopyrrolidin-3-yl)-3,3-diphenylpropanamide (CAS 1396888-08-6)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(pyridin-3-yl)methyl]-1H-pyrrole-2-sulfonamide (CAS 338406-64-7)
- 3-{[(3,5-Difluorobenzyl)oxy]methyl}pyrrolidinehydrochloride (CAS 1219976-59-6)
- trans--1-Ethynyl-4-methoxycyclohexane (CAS 2472890-09-6)
- 4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid (CAS 856257-31-3)
- 4-Phenoxynicotinaldehyde (CAS 114077-83-7)
- 2-Amino-N-(2-(dimethylamino)cyclohexyl)-N-ethylacetamide (CAS 1353962-08-9)
- 6-α-D-Glucopyranosylmaltotriose tetradecaacetate (CAS 852311-55-8)
- Semaglutide Impurity 3 (CAS CATO-C4X-22263)
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