Zoledronic Acid Impurity 8 CAS 1334703-07-9
| CAS No. | 1334703-07-9 |
| Molecular Formula | C11H17N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Zoledronic Acid Impurity 8 (CAS 1334703-07-9) is a certified pharmaceutical impurity reference standard with the molecular formula C11H17N2O4Cl and a molecular weight of 276.72 g/mol.
The molecular framework of Zoledronic Acid Impurity 8 (C11H17N2O4Cl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Zoledronic Acid Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H17N2O4 Cl |
| Molecular Weight | 276.72 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Zoledronic Standards
- Zoledronic-d (CAS 1134798-26-7)
- Zoledronic Impurity 4 (CAS 117255-11-5)
- zoledronic acid (CAS 118072-93-8)
- Zoledronic Acid EP Impurity D-13C2-15N2 (CAS 1184983-00-3)
- Zoledronic Acid Impurity 20 (CAS 131468-90-1)
- Zoledronic Acid EP Impurity A (CAS 1627731-60-5)
- Zoledronic Acid Impurity 2（Zoledronic Acid EP Impurity B） (CAS 1627731-61-6)
- Zoledronic Acid EP Impurity B (CAS 1632236-60-2)
Recommended Standards
- Phoxim Impurity 8 (CAS CATO-C4X-29978)
- Cefmetazole Impurity 64 (CAS CATO-C4X-150764)
- Norfloxacin Impurity 44 (CAS 140700-98-7)
- 2-[(4-amino-5-cyclohexyl-4h-1,2,4-triazol-3-yl)sulfanyl]acetic acid (CAS 560995-24-6)
- 1-Methyl-d3-histamine 2HCl (CAS 344299-49-6)
- rac Tamsulosin Hydrochloride (CAS 80223-99-0)
- Methyl 2-(2,6-dichloropyrimidin-4-yl)acetate (CAS 1048389-52-1)
- 8-Propyl-8-azabicyclo[3.2.1]octan-3-ol (CAS 859990-64-0)
- 2H-Pyran-2,5-diol (CAS 113895-83-3)
- DAPK Substrate Peptide (CAS 386769-53-5)
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