Norfloxacin Impurity 44 CAS 140700-98-7
| CAS No. | 140700-98-7 |
| Molecular Formula | C11H9ClFNO |
| Molecular Weight | 225.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Norfloxacin Impurity 44 (CAS 140700-98-7, C11H9ClFNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H9ClFNO, Norfloxacin Impurity 44 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 225.65 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9ClFNO |
| Molecular Weight | 225.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Norfloxacin Standards
- Norfloxacin lmpurity 28 (CAS 1119454-98-6)
- Norfloxacin lmpurity 29 (CAS 1529604-41-8)
- Norfloxacin Impurity 38 (CAS CATO-C4X-146838)
- Norfloxacin Impurity 12 (CAS 75001-63-7)
- Norfloxacin Impurity 3 (CAS 16600-24-1)
- Norfloxacin Impurity 32 (CAS 70032-16-5)
- Norfloxacin Impurity 57 (CAS CATO-C4X-146857)
- Norfloxacin Impurity 52 (CAS 7251-32-3)
Recommended Standards
- Vonoprazan Impurity 250 (CAS CATO-C4X-1020250)
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- 4-Chloromethyl-2-(4-fluorophenyl)-5-methyl-oxazole (CAS 625826-69-9)
- 4-((6-Chloropyridin-3-yl)methyl)piperazin-2-one (CAS 1016705-94-4)
- Fulvestrant Impurity 8 (CAS 252947-01-6)
- Avatrombopag Impurity 34 (CAS CATO-C4X-223434)
- Baricitinib Impurity 76 (CAS CATO-C4X-226076)
- N-(2-((4-Fluorophenyl)sulfonyl)-2-(thiophen-2-yl)ethyl)benzenesulfonamide (CAS 896346-72-8)
- 1-(4-Chlorophenyl)-2-{[5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]sulfanyl}ethan-1-one (CAS 478063-33-1)
- 2-Nitro-4-(trifluoromethyl)benzamide (CAS 22227-55-0)
- (S)-1-(2-chlorophenyl)ethan-1-amine hydrochloride (CAS 1398109-11-9)
- 3-Cyclopropoxy-2-methoxyisonicotinic acid (CAS 1243407-93-3)
- N-(Pyrimidin-2-yl)picolinamide (CAS 848308-21-4)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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