(6S)-Hydroxy Simvastatin CAS 133645-46-2
| CAS No. | 133645-46-2 |
| Molecular Formula | C25H38O6 |
| Molecular Weight | 434.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(6S)-Hydroxy Simvastatin (CAS 133645-46-2) is a high-purity analytical reference standard with the molecular formula C25H38O6 and a molecular weight of 434.57 g/mol.
(6S)-Hydroxy Simvastatin (C25H38O6) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), (6S)-Hydroxy Simvastatin meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H38O6 |
| Molecular Weight | 434.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
Related S Standards
- 3”-Hydroxy simvastatin (CAS 126313-98-2)
- 3-Hydroxy Simvastatin (CAS 134523-09-4)
- 5(S)-Hydroxy Simvastatin (CAS 149949-05-3)
- 5-Hydroxy-7-(2-hydroxy-4-methoxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-g]chromen-6-one (CAS 30431-68-6)
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Recommended Standards
- 6′-Hydroxymethyl Simvastatin (CAS 128241-03-2)
- E-5324 (CAS 141799-76-0)
- (5β,6β)-Epoxy-17α-hydroxy-pregnane-3,20-dione-3,20-bis(ethyleneketal) (CAS 117898-52-9)
- Methyl (S)-2-Amino-3-[4-[4-(1-Boc-4-piperidyl)butoxy]phenyl]propanoate (CAS 142373-57-7)
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- Sodium 3,5-bis(trifluoromethyl)benzoate (CAS 87441-96-1)
- 1-(2-((2-Hydroxyethoxy)methyl)pyrrolidin-1-yl)ethanone (CAS 1353980-17-2)
- Telmisartan Impurity 78 (CAS CATO-C4X-135978)
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- 2-(4-Fluorophenyl)acetic acid (CAS 405-50-5)
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- (3-(Methylamino)piperidin-1-yl)(o-tolyl)methanone hydrochloride (CAS 1840231-61-9)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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