4-(2-Iodobenzyl)tetrahydro-2H-pyran-4-carboxylic acid CAS 1338495-25-2
| CAS No. | 1338495-25-2 |
| Molecular Formula | C13H15IO3 |
| Molecular Weight | 346.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(2-Iodobenzyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 1338495-25-2), molecular formula C13H15IO3 and molecular weight 346.16 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 4-(2-Iodobenzyl)tetrahydro-2H-pyran-4-carboxylic acid (C13H15IO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 346.16 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H15IO3 |
| Molecular Weight | 346.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | I-containing |
Related Iodobenzyl Standards
- 2-(4-(4-Iodobenzyl)piperazin-1-yl)ethan-1-ol (CAS 1345098-44-3)
- 2-((4-Iodobenzyl)thio)-5-methyl-1,3,4-thiadiazole (CAS 824941-60-8)
- 1-(4-Iodobenzyl)-4-propoxy-1H-pyrazole (CAS 2004573-97-9)
- N-(3-Iodobenzyl)-N-methyl-2-(pyridin-2-yl)ethan-1-amine (CAS 1850268-44-8)
- 4-((4-Iodobenzyl)oxy)benzaldehyde (CAS 443289-91-6)
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- 2-((2-Iodobenzyl)(isopropyl)amino)acetic acid (CAS 1353946-00-5)
Recommended Standards
- 1-(6-Iodo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-1-yl)-2,2-dimethylpropan-1-one (CAS 1228665-79-9)
- 2-(4-Chloro-2-methylphenoxy)-N-(4-chlorophenyl)-2,2-difluoroacetamide (CAS 339010-93-4)
- 2-(1,3-Benzodioxol-5-yl)-6-chloroquinoline-4-carbonyl chloride (CAS 1160263-50-2)
- 3-(1,3-Dioxan-2-yl)-1-(2-iodophenyl)propan-1-one (CAS 898785-46-1)
- 2,2’,5,5’-tetramethoxy-1,1’-biphenyl-4,4’-diamine (CAS 23071-40-1)
- 2,2,2-Trifluoro-1-(oxiran-2-yl)-1-phenylethan-1-ol (CAS 351003-37-7)
- 2-(4-Formyl-1h-pyrazol-1-yl)ethyl acetate (CAS 1315367-26-0)
- 1-(Allyloxy)-3-bromo-5-fluorobenzene (CAS 477956-04-0)
- 4-Fluoro-N-(3-methoxybenzylidene)aniline (CAS 202073-14-1)
- Asenapine Impurity 4 (CAS CATO-C4X-19474)
- Trazodone Impurity 99 (CAS CATO-C4X-177299)
- (R)-3-amino-4-(4-iodophenyl)butanoic acid hydrochloride (CAS 332061-76-4)
- 7-Bromo-1-methyl-1,2,3,4-tetrahydro-5H-benzo[e][1,4]diazepin-5-one (CAS 455885-79-7)
- Galanin Message Associated Peptide (1-41) amide trifluoroacetate salt (CAS 132699-74-2)
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